Outcome of Mood Disorders Before Psychopharmacology


A “systematic review” of all outcome studies of patients with mood disorders, in the March issue of the Australia & New Zealand Journal of Psychiatry, finds that “the long-term outcome for patients with mood disorders in the predrug era was reasonably positive. Most patients recovered and the majority seemed to remain well after their recovery.” In the modern era, however, “the recurrence of mood episodes appears to have significantly increased.” The authors conclude that “These data . . . provide no comfort for those, including ourselves, who have believed that drugs provide an effective prophylactic treatment for at least a substantial minority of patients with affective disorders.”

Article →

Mulder, R., Frampton, C.; Outcome of mood disorders before psychopharmacology: A systematic review. Australia & New Zealand Journal of Psychiatry. March, 2014. 48(3) 224-236 doi: 10.1177/0004867413514490

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].


  1. This article is great and is in keeping with Bob Whitaker’s dedicated work with the Wunderink and other studies showing the same results that Dr. Thomas Insel supported on his web site shortly after Bob wrote his “ultimatum” to biopsychiatry that ignoring such results would mean that this profession should no longer be in charge of such “mental health.”

    Since Australia had one of the greatest preventive neuroleptic child drugging advocates (who is also a great proponent of forced “treatment/drugging” for one and all) from which he ultimately backed off based on studies and other information, it is especially encouraging that this study comes from that country.

    Hope to see many more articles like this from every country pushing these lethal drugs for lethal stigmas like schizophrenia and bipolar and see the major change Bob Whitaker is advocating!



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