National Institute of Mental Health Director Thomas Insel laments the lack of reproducibility in such a large majority of mental health-related research. He describes a few of the most common reasons besides outright fraud or “hacking” of data to produce significant results, such as “biological variability, flawed experimental design, or flawed analysis.” He argues that more open clinical trial data sharing could help.
P-Hacking (NIMH Director’s Blog, November 14, 2014)
