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  1. This is good news! The active ingredient in Alkermes’ drug, ALKS 5461, is buprenorphine, an opioid. Buprenorphine is found in Suboxone, which is used as an opioid substitution drug. It has a serious addiction potential; and it is a Schedule III controlled substance. I’ve talked with heroin addicts who said it’s harder to taper off of, or withdraw from than heroin or methadone.