Might Antidepressants Create Treatment Resistance?


From Psychiatric Times: A recent study of individuals diagnosed with bipolar II disorder found that patients who have taken antidepressants in the past are less likely to respond to treatment with mood stabilizers.

“…receiving antidepressants in the past was associated with being less likely to respond to lithium once someone finally treated their bipolar II disorder with a mood stabilizer. And it was proportional: the more antidepressants, the lower the chance of response or remission.”

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