Researchers Plan to Retract Landmark Alzheimer’s Paper Containing Doctored Images


From Science: “Authors of a landmark Alzheimer’s disease research paper published in Nature in 2006 have agreed to retract the study in response to allegations of image manipulation. University of Minnesota (UMN) Twin Cities neuroscientist Karen Ashe, the paper’s senior author, acknowledged in a post on the journal discussion site PubPeer that the paper contains doctored images. The study has been cited nearly 2500 times, and would be the most cited paper ever to be retracted, according to Retraction Watch data.

. . . After initially arguing the paper’s problems could be addressed with a correction, Ashe said in another post last week that all of the authors had agreed to a retraction—with the exception of its first author, UMN neuro-scientist Sylvain Lesné, a protégé of Ashe’s who was the focus of a 2022 investigation by Science. A Nature spokesperson would not comment on the journal’s plans.

‘It’s unfortunate that it has taken 
2 years to make the decision to retract,’ says Donna Wilcock, an Indiana University neuroscientist and editor of the journal Alzheimer’s & Dementia. ‘The evidence of manipulation was overwhelming.'”

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