ADRs correlate well with genotype. They occur on toxicity as well as on sudden changes up or down. Side effects like suicidality persist well beyond five half lives it takes to clear the drug. Five weeks to 81 days for Prozac. No drug in body. Pill taken 8AM produces different blood level after different periods. And higher levels in reduced metabolisers. Danger periods on starting and fast stopping. Blood levels and doses of two drugs can be normal but they might be synergistic for ADRs. Steady state is a myth. IMs are at greater risk than PMs as side effects creep up unrecognised and are not as dramatic as PMs. Most at risk of suicide or death from intoxication are UMs. They die from prodrugs like Tramadol and oxycodone and from drugs with toxic first metabolites. And respond to nothing.