Thursday, February 2, 2023

Tag: genetics of psychiatric disorders

Schizophrenia Twin Research as Reported in The Gene: An Intimate History...

In his 2016 book The Gene: An Intimate History, cancer physician and researcher Siddhartha Mukherjee chronicled the initial idea of the gene, taking readers through the history of genetics up to the current “post-genome” period by interweaving science, social history, and his own personal narrative. In the process he documented some of the crimes of the eugenics movement and the monstrous atrocities committed by German National Socialism in the name of eugenics and biology, while noting the Nazi’s promotion of twin research. He also criticized aspects of intelligence testing and genetic theories of racial inferiority based on IQ tests. At the same time, Mukherjee supported and promoted many contemporary behavioral genetics positions.

Twin Method Assumptions are Indefensible, but are Useful to the Rich...

The wealthy, and the institutions they finance and promote, look favorably upon research whose authors claim that economic disparities are rooted in biology, and are not harmful to humanity as a whole. But there are countless obvious real-world examples showing that political policies, social struggles, and public health programs, including those involving the adjustment of income differences, lead to improved health and well-being.

The Anorexia Nervosa Genetics Initiative

Psychiatry assumes that individuals who meet its vague criteria for anorexia nervosa have a disease, and the "disease-causing problem" resides in the genome. If we wish to understand what motivates individuals who systematically under-nourish themselves, however, we need to do two things: Abandon the empty, disempowering psychiatric labels, and recognize that it is through the uniqueness of each individual that we come to understand his or her perspective, and second, we need to sit down with the individual in a spirit of trust and collaboration, and listen to his or her concerns.

Comments on Jeffrey Lieberman and Ogi Ogas’ Wall Street Journal Article...

The March 3rd, 2016 edition of the Wall Street Journal featured an article by past President of the American Psychiatric Association (APA) Jeffrey Lieberman and his colleague, computational neuroscientist Ogi Ogas. The article was entitled “Genetics and Mental Illness—Let’s Not Get Carried Away.” In their piece, the authors started by expressing the belief that a recent study identified a gene that causes schizophrenia, and then discussed whether it is desirable or possible to remove allegedly pathological genes in the interest of creating a future “mentally perfect society.” The authors of the article, like many previous textbook authors, seem unfamiliar with the questionable “evidence” put forward by psychiatry as proof that its disorders are “highly heritable” In fact, DSM-5 Task Force Chair David Kupfer admitted that “we’re still waiting” for the discovery of “biological and genetic markers” for psychiatric disorders.

“Mental Illness and Familial Influences”

"Let us be clear that claims about established genetic or biochemical causation for mental distress are, as things stand, entirely fictional," writes Dr Lucy...

“Bewitching Science” Revisited: Tales of Reunited Twins and the Genetics...

In this article I will attempt to debunk one of the great “scientific” smoke and mirrors shows of the past half century—the claim that stories of reunited separated MZ (monozygotic, identical) twin pairs indicate that heredity plays a major role in causing human behavioral differences. These stories, which are often used to sell the false ideology of genetic determinism, have entered the public imagination in a way that academic research results never could. Here I will show that these stories provide no evidence whatsoever that (as yet undiscovered) “genes for behavior” influence human behavioral development.

All in the Brain? An Open Letter Re: Stephen Fry’s Assumptions...

Stephen Fry’s exploration of manic depression (in the current BBC series on mental health, ‘In the Mind‘) has drawn both praise (because of his attempts to destigmatize mental illness) and criticism (because he appears to have a very narrow biomedical understanding of mental illness).  I have sent an open letter to the actor which challenges some of his assumptions about mental illness, and offers a very different understanding to that promoted in his recent television programme.

Breaking News! The Cause of Schizophrenia Finally Discovered!(?)

On January 27, 2016, a study1 was published online in the prestigious journal Nature that touted the possibility of discovering some potential biological origins of an "illness" called "schizophrenia" Subsequently, headlines across the world beamed excited proclamations of the latest breakthrough to occur in psychiatric research. The problem is, there is nothing profound about this study at all and, in fact, it is one of the least profound studies to emerge in the last few years on the topic of "schizophrenia." It ignores the robust support that has accumulated that undermines the genetic disease model of "mental illness" and the categorical understanding of experiences falling under the umbrella term "schizophrenia."

Schizophrenia and Genetics: A Closer Look at the Evidence

“The substantial hereditary component in schizophrenia,” a pair of researchers wrote in 1993, “is surely one of the two or three best-established facts in psychiatry.” But is it really? For mainstream psychiatry and psychiatric genetics, schizophrenia is “a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%,” or a “highly heritable neuropsychiatric disorder of complex genetic etiology.” Many commentators have challenged these claims, and some have challenged the concept of schizophrenia itself.

Twin Studies are Still in Trouble: A Response to Turkheimer

Human behavioral genetics and its allied field of psychiatric genetics are in trouble, as unfulfilled gene discovery expectations during the “euphoria of the 1980s” have continued to the present day, leading to researchers’ “nonreplication curse” dysphoria of the 2010s. In my recent book The Trouble with Twin Studies: A Reassessment of Twin Research in the Social and Behavioral Sciences, I presented a detailed argument that genetic interpretations of the common “classical twin method” finding that reared-together MZ twin pairs resemble each other more (correlate higher) for behavioral characteristics than do reared-together same-sex DZ twin pairs are invalid because, among other reasons, the twin method’s crucial MZ-DZ “equal environment assumption” (EEA) is false.

Ernst Rüdin: The Founding Father of Psychiatric Genetics

In a 2013 edition of the Journal of the History of Biology, Norbert Wetzel and I published an article on the Swiss-German psychiatric geneticist Ernst Rüdin (1874-1952) and his close colleagues, and how their work and crimes in the Nazi era have been discussed or ignored by contemporary psychiatric genetic writers and researchers. Here I would like to summarize the main points we raised in that article, and to make several additional observations. Whether Rüdin reluctantly aided and helped implement the “euthanasia” killing program in support of the war effort, or more likely, that he saw it as the crowning achievement of his decades of psychiatric genetic research based on racial hygienic (eugenic) principles, is an issue that may be decided in the future.

Are DSM Psychiatric Disorders “Heritable”?

A key psychiatric genetic concept is heritability. The concept was originally developed as a tool to help predict the results of selective breeding programs of farm animals,1 but has been extended in the past few decades as an indicator of the strength or magnitude of genetic influences on various psychiatric disorders and behavioral characteristics. Numerical heritability estimates have been a mainstay of the field of behavioral genetics, but here I would like to focus on problems with the heritability concept in psychiatry, while keeping in mind that most of the points made here and by previous critics apply to the use of heritability estimates in all areas of human behavior.

The Latest News from Twin Research: The Genetic Influence on Political...

There seems to be no end to illogical and even comical “findings” from MZ-DZ twin method comparisons, where the original twin researchers argue that the greater behavioral resemblance of reared-together MZ (monozygotic, identical) versus same-sex DZ (dizygotic, fraternal) twin pairs demonstrates the “heritability” of the behavioral characteristic in question. Among these we find a twin study whose authors concluded in favor of a genetic basis for being a “born again Christian” (65% heritability), another that found important genetic influences on tea and coffee drinking preferences, and still another that found that the heritability of “loneliness in adults” is 48%.