Tuesday, November 13, 2018

Bias, Corruption & Accountability

whistleblower

Heroes of Science: Survival of a Whistleblower

I am just the messenger, the symbol that healthcare is in many ways absurd and harmful because the drug industry is too powerful. The Cochrane Collaboration is in deep crisis because it is too close to industry, practices scientific censorship and has a business model that focuses on “brand” and “our product” rather than getting the science right.

New Study Explores Approaches to Discontinuing Antidepressants

Psychiatrist and psychologist outline pharmacological and psychotherapeutic strategies for discontinuing antidepressants.
twins

Bad-Science Warning: The “Minnesota Study of Twins Reared Apart” (MISTRA)

The huge impact of the MISTRA, in addition to the harmful and regressive social and political policy implications that flow from it, necessitates a detailed analysis of the “science” behind the study’s major claims and conclusions. Here I offer a new critique of this famous and influential “separated twin study.”

Multiple Researchers Examining the Same Data Find Very Different Results

A new study demonstrates how the choice of statistical techniques when examining data plays a large role in scientific outcomes.

Sociologists Interrogate Neurobiological Explanations in Criminology

A discourse analysis conducted by sociologists finds problematic assumptions and practices in the field of neurocriminology.

Are Depression Guidelines Missing the Evidence for Exercise?

A recent review suggests that depression guidelines do not incorporate evidence for exercise within a stepped-care approach and may be over-reliant on pharmacological treatments.

About 1 in 100 Children Treated with Ritalin Experience a Serious Adverse Event

A recent Cochrane review has found that serious adverse events occur for about 1% of children and adolescents treated with Ritalin.

New Report Points to Gaps in the Evidence for Pediatric Bipolar Disorder

A new report on pediatric bipolar critically examines the current evidence base and calls for more research before the diagnosis is used.

Do Family Interventions for Psychosis Translate in China?

Researchers explore how family interventions for psychosis might be adapted to China’s emerging integrated mental health care landscape.

Pooling Data May Hide Negative Outcomes for Antidepressants

A new study, published in Psychological Medicine, found evidence for a specific type of publication bias distorting the evidence about antidepressant efficacy.
Cochrane Collaboration

The Cochrane Collaboration Has Failed Us All

The "independent report" that investigated the complaints against Peter Gøtzsche (which included a complaint from E. Fuller Torrey) reveals that they arose in connection with his criticisms of psychiatric drugs. The Cochrane Collaboration's ouster of Gøtzsche betrays a commitment to open-minded science that is vital to serving the public good.

SNRIs Added to the List of Drugs with Potential Withdrawal Symptoms

New research suggests that clinicians should exercise caution prescribing SNRIs as first-line treatment for mood and anxiety disorders.

Two-Thirds of Schizophrenia Patients Do Not Remit on Antipsychotics

A new analysis of antipsychotic treatment of schizophrenia (published in Schizophrenia Bulletin) has found that two-thirds of patients treated this way do not experience symptom remission.

Systematic Review Finds Antidepressant Withdrawal Common and Potentially Long-lasting

Prominent researchers conduct a review of antidepressant withdrawal incidence, duration, and severity. Results lead to call for new clinical guidelines.

Nonclinical Factors are Associated with Long-Term Benzodiazepine Use in Older Adults

White race and size of initial prescription, along with poor sleep quality, are associated with long-term benzodiazepine use in older adults.

Less Than Half of Clinical Trials Comply with Legislation to Accurately Report Results

A new study finds that sponsors of clinical trials in the EU continue to fail at reporting their results as required by recent legislation.

Reanalysis of STAR*D Study Suggests Overestimation of Antidepressant Efficacy

Reanalysis of the original primary outcome measure in the STAR*D study suggests STAR*D findings inflate improvement on antidepressant medication and exclusion criteria in conventional clinical trials results in overestimation of antidepressant efficacy.

DACA has “Immediate and Positive” Impact on Lives of Immigrant Students, Study Finds

New research demonstrates the benefits and complexities for immigrants transitioning from undocumented to DACA status.

International Study Documents Widespread Distress in College Students

An international study of college students reveals ubiquitous social and emotional challenges faced by young adults.

Rates of ADHD Diagnosis and Prescription of Stimulants Continue to Rise

Two new articles find that rates of ADHD diagnosis and stimulant prescription continue to rise all over the world.

Antidepressant Use Climbs as Patients Find it Difficult to Discontinue

Findings point to the role of withdrawal symptoms and prescriber practices in long-term antidepressant use.

New Review of Antipsychotics for Schizophrenia Questions Evidence for Long Term Use

A systematic review of the limited research available on the long-term effects of antipsychotics finds fewer symptoms in those off of the drugs.

Minimal Evidence for Disruptive Mood Dysregulation Disorder in Childhood

Researchers offer a critical take on the inclusion of the Disruptive Mood Dysregulation Disorder in the DSM-V.

Researcher Challenges Clinical Effectiveness of Antidepressants

A new article in BMJ Evidence-Based Medicine addresses common misinterpretations of the efficacy research on antidepressants.

Researcher Critically Examines Movements for Global Mental Health

China Mills raises concerns that global mental health movements obscure social determinants of health and naturalize Western mental health concepts.

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