A trial of a new process of identifying drugs that can disrupt sex hormones singled out Paxil from 446 common drugs as having a weak estrogenic effect that could promote the growth of breast tumors in women. The study may shed light on previous studies that found women taking Paxil were more likely than those taking other antidepressants to die of breast cancer when also taking tamoxifen to prevent breast cancer recurrence.
Chen, S., Zhou, D., Hsin, L., Kanaya, N., et al; AroER Tri-Screen™ is a Biologically Relevant Assay for Endocrine Disrupting Chemicals Modulating the Activity of Aromatase and/or the Estrogen Receptor. Toxicological Sciences. Online February 4, 2014. doi: 10.1093/toxsci/kfu023