A trial of a new process of identifying drugs that can disrupt sex hormones singled out Paxil from 446 common drugs as having a weak estrogenic effect that could promote the growth of breast tumors in women. The study may shed light on previous studies that found women taking Paxil were more likely than those taking other antidepressants to die of breast cancer when also taking tamoxifen to prevent breast cancer recurrence.
Abstract →
Chen, S., Zhou, D., Hsin, L., Kanaya, N., et al; AroER Tri-Screen™ is a Biologically Relevant Assay for Endocrine Disrupting Chemicals Modulating the Activity of Aromatase and/or the Estrogen Receptor. Toxicological Sciences. Online February 4, 2014. doi: 10.1093/toxsci/kfu023
Of further interest:
Antidepressant Paxil boosts estrogen activity, new study finds (City of Hope)
New test suggests antidepressant Paxil may promote breast cancer (LA Times)
Popular antidepressant linked to increased breast cancer risk (RT)
Study: Paxil Could Promote Breast Tumor Growth In Women (CBS Atlanta)
Possible Link Between Paxil and Breast Cancer Found (Yakkity Yak)
City of Hope Researchers Develop Test to Assess Effect of More Than 1,500 Chemicals on Estrogen (Newswise)