NMS in 2nd Gen. Antipsychotics: Similar, But Younger


A study released online today by the British Journal of Psychiatry shows that the clinical profile of neuroleptic malignant syndrome (NMS) is similar in 1st- v. 2nd-generation antipsychotics. Patients presenting with NMS from 2nd generation are younger, with less rigidity and a lower mortality rate.

Abstract → 

Trollor, J. Chen, X. Chitty, K. Sachdev, P. Comparison of neuroleptic malignant syndrome induced by first- and second-generation antipsychotics, British Journal of Psychiatry, Published online May 26, 2012


Mad in America hosts blogs by a diverse group of writers. These posts are designed to serve as a public forum for a discussion—broadly speaking—of psychiatry and its treatments. The opinions expressed are the writers’ own.


Mad in America has made some changes to the commenting process. You no longer need to login or create an account on our site to comment. The only information needed is your name, email and comment text. Comments made with an account prior to this change will remain visible on the site.

Previous articleLosing Your Home While Pregnant Makes You Depressed
Next articlePsychiatric Drugs: an Increasing Portion of Prescription Costs
Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].


  1. Hello Kermit,

    I am like a little kid with her wobbly tooth dropped out when it comes to any mention of Neuroleptic Malignant Syndrome, since I have had it and want to brag to the world that I was terribly brave and didn’t cry.
    But it is so rare that when I do steer the chat onto my near death experience nobody local seems remotely interested. That said, I read a report of an upsurge in NMS cases amongst covid patients who are given antipsychotics in intensive care to settle their delirium hallucinations. I feel antipsychotics are as metres of woven chemical binders, like mummy embalming bandages that restrict the raging tempest inside and even pep the muffled interior with a dusting of akasthesia. I cannot imagine a worse time to have inner restlessness than when pronged by a vebtilator tube. The fact that NMS causes a cytokine storm and…like a matching pair…so does brutal covid 19…and you probably do not have to be a little kid with a loose tooth to figure out that cannot be helpful.

    In India thousands will have died today of covid. I do hope some of the wealthier who could get hospital care were not sent to their eternal rest with a cytokine storm caused by preventable NMS. Another case of medicine botching up medicine.

    Report comment