NMS in 2nd Gen. Antipsychotics: Similar, But Younger


A study released online today by the British Journal of Psychiatry shows that the clinical profile of neuroleptic malignant syndrome (NMS) is similar in 1st- v. 2nd-generation antipsychotics. Patients presenting with NMS from 2nd generation are younger, with less rigidity and a lower mortality rate.

Abstract → 

Trollor, J. Chen, X. Chitty, K. Sachdev, P. Comparison of neuroleptic malignant syndrome induced by first- and second-generation antipsychotics, British Journal of Psychiatry, Published online May 26, 2012


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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected]


  1. Hello Kermit,

    I am like a little kid with her wobbly tooth dropped out when it comes to any mention of Neuroleptic Malignant Syndrome, since I have had it and want to brag to the world that I was terribly brave and didn’t cry.
    But it is so rare that when I do steer the chat onto my near death experience nobody local seems remotely interested. That said, I read a report of an upsurge in NMS cases amongst covid patients who are given antipsychotics in intensive care to settle their delirium hallucinations. I feel antipsychotics are as metres of woven chemical binders, like mummy embalming bandages that restrict the raging tempest inside and even pep the muffled interior with a dusting of akasthesia. I cannot imagine a worse time to have inner restlessness than when pronged by a vebtilator tube. The fact that NMS causes a cytokine storm and…like a matching pair…so does brutal covid 19…and you probably do not have to be a little kid with a loose tooth to figure out that cannot be helpful.

    In India thousands will have died today of covid. I do hope some of the wealthier who could get hospital care were not sent to their eternal rest with a cytokine storm caused by preventable NMS. Another case of medicine botching up medicine.