Antidepressants Linked to Osteoporosis and Fractures

Kermit Cole
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Researchers from Switzerland, the U.K., Belgium, Denmark, Canada, Italy, Austria and the U.S. review the current evidence linking antidepressants to loss of bone mineral density and osteoporosis in an article released online May 30 by the journal Bone. They find that depression itself increases the risk for fractures, and that use of SSRIs and tricyclics increases fracture risk by as much as twofold in a dose-response relationship. The increased risk is greatest in the early stages of treatment, and diminishes to baseline in the year after discontinuation.

Abstract → 

Rizzoli, R. Cooper, C. et. al; “Antidepressant Medications and Osteoporosis,” Bone, online May 30, 2012

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Mad in America hosts blogs by a diverse group of writers. These posts are designed to serve as a public forum for a discussion—broadly speaking—of psychiatry and its treatments. The opinions expressed are the writers’ own.

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected]

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