Researchers from Switzerland, the U.K., Belgium, Denmark, Canada, Italy, Austria and the U.S. review the current evidence linking antidepressants to loss of bone mineral density and osteoporosis in an article released online May 30 by the journal Bone. They find that depression itself increases the risk for fractures, and that use of SSRIs and tricyclics increases fracture risk by as much as twofold in a dose-response relationship. The increased risk is greatest in the early stages of treatment, and diminishes to baseline in the year after discontinuation.
Rizzoli, R. Cooper, C. et. al; “Antidepressant Medications and Osteoporosis,” Bone, online May 30, 2012
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