Published Clinical Trials are Misleading, PLoS Says


Research from the Center for Clinical Trials at Johns Hopkins finds troubling differences between publicly available information on medications and the information that pharmaceutical companies possess. The paper, made available online yesterday by the Public Library of Science in PLoS Medicine, examines information made available as a result of a lawsuit against Pfizer regarding gabapentin (Neurontin) and finds that articles published in 10 peer-reviewed journals were biased and misleading despite appearing to follow standard protocols.

Abstract and Editors’ Summary →

Vedula, S., Li, T., Dickersin, K. Differences in Reporting of Analyses in Internal Company Documents Versus Published Trial Reports: Comparisons in Industry-Sponsored Trials in Off-Label Uses of Gabapentin. PLoS Medicine. Online January 29, 2013

Of further interest:
Published clinical trials shown to be misleading (Science News)

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].