Antipsychotics do not Result in Neurocognitive Improvement


Researchers in London and Spain, in a prospective, randomized, study of long-term (3 year) effects of first- and second-generation antipsychotics on neurocognition in 79 patients following a “first episode of schizophrenia spectrum disorders”, find that “haloperidol, olanzapine, and risperidone have not demonstrated substantial neurocognitive effectiveness.” Results appeared online in Psychopharmacology on March 2, 2013.

Article →Ayesa-Arriola, R., Rodriguez-Sanchez, J., Perez-Iglesias, R., et al; Long-Term (3-Year) Neurocognitive Effectiveness of Antipsychotic Medications in First-Episode Non-Affective Psychosis. Psychopharmacology. Online March 2, 2013

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].


  1. Haloperidol, olanzapine and risperidone did definitely NOT help my son as far as cognition was concerned. These meds actually stopped him from reasoning out his problems. Once he took himself off the antipsychotic medication, he could see straight away the absurdity of his assumptions: that the whole British police force was after him and that spies were lurking everywhere. These meds actually kept him trapped in the delusional world he had created during fever and infection.

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  2. ‘The study also underscores the importance of exploring new drugs for the treatment of cognitive impairments and associated functional disabilities in schizophrenia.’

    ‘Schizophrenia’ costs the UK £36,000 per sufferer per year. The Medical Treatment eventually kills the patient. New drugs are killing people quicker.

    My own experience of longterm Recovery and return to Taxpaying Status was through the Talking Treatments.

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