Researchers from Columbia University and the New York State Psychiatric Institute test the behavioral effects of SSRIs on Pavlovian fear conditioning in rats, and propose a model by which acute SSRI administration alters neural activity in the amygdala and hippocampus in a way that reduces anxiety symptoms but impairs the ability to learn new responses anxiety. Results appear in this month’s Neuroscience.
Burghardt, N., Bauer, E.; Acute and Chronic Effects of SSRI Treatment on Fear Conditioning: Implications for Underlying Fear Circuits. Neuroscience. Online June 1, 2013