Antidepressants for Fibromyalgia: Worse Long-Term Symptomatic and Functional Outcome


Research from Italy finds that though antidepressants have been shown to be effective in treating fibromyalgia in the short term, “in a small sample of women with fibromyalgia, after a year of observation, those who had followed a therapy with antidepressants experienced a worst impact of the disease on their daily lives. At the end of the trial the quality of life and the disability linked to bipolar symptoms were worse in the group treated with antidepressants.”

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Carta, M., Ruggiero, V., Sancassiani, F., Cutrano, F., et al; The Use of Antidepressants in the Long-Term Treatment Should not Improve the Impact of Fibromyalgia on Quality of Life. Clinical Practice & Epidemiology in Mental Health. Online July 12, 2013. doi:  10.2174/1745017901309010120

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].


  1. Mania, suicide, violence, akathisia and a host of other lethal effects of so called antidepressants are listed in the Physician’s Desk Reference. It’s also been established by many experts that these poison drugs are no better than placebo for their stated purpose as “antidepressants,” and in fact, can make it much worse and even permanent.

    Thus, I find this article disgusting and revolting for its fraudulent claims that those already suffering from fibromyalgia are then said to be suffering from the fraud fad bipolar disorder when they obviously had a typical reaction to these toxic, dangerous, useless drugs. What a bunch of heartless, lying and or incompetent frauds.

    On the other hand, this article does serve as an excellent warning for anyone thinking of using these toxic, life destroying drugs for this or any other illness. Caveat Emptor!!

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