An article in Biological Psychiatry that asks “Is Aberrant Functional Connectivity A Psychosis Endophenotype” inspires reflection on how new findings of brain science suggest rethinking current diagnostic paradigms. “Our current diagnostic system, DSM-V represents a very reasonable attempt to classify patients by their symptoms. Symptoms are an extremely important part of all medical diagnoses, but imagine how limited we would be if we categorized all forms of pneumonia as ‘coughing disease,” commented Dr. John Krystal, Editor of Biological Psychiatry. “It is evident that neither our genomes nor our brains have read DSM-V in that there are links across disorders that we had not previously imagined.”
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