Psychiatric Times has published a discussion of the research comparing the effectiveness of antidepressant medications under different conditions. “First, there seem to be no significant differences among [different antidepressants],” states author Dr. Steve Balt. “Second, and somewhat surprisingly, antidepressant effectiveness is quite low.” When discussing the significance of the placebo effect, Balt cites research suggesting that “the quality of the therapeutic alliance between prescriber and patient is sometimes a better predictor of patient outcome than which drugs are prescribed. One study found that “effective” prescribers obtained better outcomes with placebos than “less effective” prescribers with active antidepressants.”
Assessing and Enhancing the Effectiveness of Antidepressants (Psychiatric Times, June 13, 2014)