New Zealand and Chinese investigators believe they have clarified the mechanisms by which second generation antipsychotics cause serious “derangements” in glucose metabolism in the human body. Reporting in Schizophrenia Research, the researchers write that previously many have assumed that these negative metabolic effects were due to increases in insulin resistance, but during more precise animal studies using clozapine they found otherwise.
“Taken together these results suggest that clozapine does not have any direct effect on glucose metabolism in the liver but it simultaneously stimulates insulin and glucagon secretion, a situation that would allow for the concurrent presence of high glucose and high insulin levels in treated animals,” conclude the researchers.
Clozapine directly increases insulin and glucagon secretion from islets: Implications for impairment of glucose tolerance (Smith, G.C. et al. Schizophrenia Research. August 2014. DOI: http://dx.doi.org/10.1016/j.schres.2014.05.003)