People who take SSRI antidepressants are twice as likely to have their dental implants fail, according to McGill University researchers. In a press release, the researchers stated that there were plausible biological explanations for the link, due to the widely-reported negative effects of SSRIs on bones.
“Because antidepressants, which are widely used around the world, are reported to increase the risk of bone fracture and reduce bone formation, we were curious to see how they might affect dental implants,” said McGill’s Faleh Tamimi in the press release. “Even so, we were surprised to discover that the negative effect of SSRIs on dental implants was so strong, almost equal to that of smoking, a well-established hazard for oral health.”
The researchers reviewed records of dental implants done over a six-year period, between 2007 – 2013, in a clinic in Moncton, New Brunswick, and followed up with patients. Of 916 dental implants done on 490 patients, of which 51 were taking SSRIs, there was a 10.64% failure rate of the implants among the people taking SSRIs.
“[W]hether they are planning to have dental implants or hip or knee prostheses, SSRI users should consult their physicians and plan carefully to ensure that the surgical treatment is successful,” said Tamimi.
Drugs for Depression Linked with Failure of Dental Implants (McGill University Press Release on Newswise, September 10, 2014.)