SSRI Does Not Improve Outcomes or Mood for Patients with Heart Failure


A study released this week in JAMA examined whether giving patients with chronic heart failure and depression the SSRI antidepressant escitalopram (Lexapro) for two years would improve their mood and health outcomes. The results of the randomized control trial reveal that the antidepressant not only failed to improve physical health outcomes but also failed to improve depression symptoms.

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Angermann CE, Gelbrich G, Störk S, et al. Effect of Escitalopram on All-Cause Mortality and Hospitalization in Patients With Heart Failure and Depression: The MOOD-HF Randomized Clinical Trial. JAMA.2016;315(24):2683-2693. doi:10.1001/jama.2016.7635. (Abstract)