When Your Antidepressant Isn’t as Safe as You Think


In this piece for Psych Central, Dr. Viatcheslav Wlassoff discusses some of the safety issues and adverse effects of antidepressants.

“When it comes to side effects, anticholinergic side effects like dryness of mouth, blurring of vision, and dizziness are common with most antidepressants. Most of them may also alter appetite and sexual function, and cause an upset stomach, joint and muscular pains, problems with drug interactions, irritability, mood changes, movement disorders and the risk of falling in the elderly, and much more. Moreover, these side effects continue to persist when the drugs are used long term.

The development of tolerance and withdrawal symptoms are widespread. Discontinuation syndrome can be really bad in many cases.”


  1. This thing about antidepressants being effective in severe depression is bogus but it’s trotted out time amd again. It was a mistaken interprtion of data that led to it. Because effectiveness is measured by the difference between placebo and treatment group, much depends on the patients’ response to placebo. In the most severe depression cases, placebo barely has an effect, but in mild to moderate cases, placebo takers report or potray a mood boost. Thereforestation the gap between drug and placebo effectiveness is greatest for severe cases, even if the drug effect per se is nil.other se just that the reduced placebo effect in severe cases increases the drug/placebo effect gap.

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