I’m getting tired of the line that “there is very little scientific knowledge about the long-term effects of the drug”. There’s plenty of knowledge gathered here in Bristol / UK where we had a recreational ketamine epidemic in the late 1990s and 2000s. Presumably, a sizeable share those taking ketamine were self-medicating. Example: “At the age of 23, Nancy had died slowly over seven years, her body trashed by a steady diet of ketamine.” https://www.vice.com/en_uk/article/av4njj/ketamine-slowly-ruins-your-bladder-and-kills-you-863 Bristol’s BRI hospital reportedly performed lots of bladder surgery during that time. I’m amazed nobody in the scientific community seems to have reached out to BRI, or to Bristol’s drug councelling services.