You raise a very important point – the cost. Believe me, that is at the forefront of the research. The ONLY way to have governments or health insurance take a treatment seriously and consider funding it is to have research clinical trials. And as we have pointed out so many times, the only way to have those trials taken seriously is to conduct them independent of the companies that make the products. That’s why we do what we do. You have to understand that drugs are equally expensive (if not more so if one takes into account the negative effects on income, contribution to physical health issues etc) but we often don’t appreciate the expense because accessing drugs is often covered by our public health care system (at least it is in Canada and NZ). So the fact that the government might pay 400 dollars an hour for a patient to see a psychiatrist is not factored into the cost when comparing meds to nutrients. The fact that even with medications someone is unable to work is not factored into the cost of the medications. And then if the drug causes an arrhythmia, then the cost associated with investigating that (several thousand) is not factored into the cost of the drug. When nutrients work, these costs are unlikely to arise. Also, we are not convinced that the testing (like for methylation) is at a stage where it is that useful. Others might disagree, but the research is not as advanced as we might like to think it is. We are looking into that issue right now in NZ and might have further information on the topic in a year or so. Understand that we have not ONLY studied the truehope products, there are others we have also studied that don’t differentiate on their B12, like Daily Essential Nutrients. Whether both forms are needed is up for debate. With more data, we can then lobby governments and politicians to consider covering this as part of the health care system. At this point in time, we have chosen to allow Big Pharma to monopolize treatment options for families. So how do we change the system and include nutrition as part of our care of those who are ill? Because ultimately the fact that drugs are covered and nutrients aren’t is what makes this option appear so unaffordable. We can’t realistically ask the companies to give it away for free! I am not involved in the costs and not here to defend the costs, but generally as a consumer, we know that cheaper products tend to have cut corners.