Friday, February 3, 2023

Tag: Genetic theories of schizophrenia

John Read and Jeffrey Masson – Biological Psychiatry and the Mass...

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On the Mad in America podcast this week, we hear from the co-authors of a paper published in the journal Ethical Human Psychology and...

Got a Gene for That? The Latest from the Chronicles of...

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Among the latest examples of profiteering from the gene fad, there is now an app to determine your personal level of gayness, and researchers claim to have finally found real biomarkers to diagnose schizophrenia through a simple hair sample! Make no mistake: this is about the religion of scientism, not about science.

Hereditary Madness? The Genain Sisters’ Tragic Story

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The story of the Genain quadruplets has long been cited as evidence proving something about the supposed hereditary nature of schizophrenia. But who wouldn’t fall apart after surviving a childhood like theirs? The doctors attributed their problems to menstrual difficulties or excessive masturbation — anything except abuse.

A Faux Test for a Faux Disease Promoted by Real Psychiatrists

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Influential psychiatrists recently called on the NHS to make a faux schizophrenia test available to patients and their families. What is most astounding about this is the complete lack of pretense. "We are so certain of our power and righteousness that we are going to tell you to your face that we are lying, and yet, we will still get our way."

Schizophrenia ‘Risk Genes’: Not So Risky if Mother’s Pregnancy Healthy

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From STAT news: "Far be it from us to tell 23andMe how to run its business, but if it or any other DNA company wants to...

Dr. Jay Joseph: Why Schizophrenia Genetic Research is Running on Empty

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Dr Jay Joseph discusses the evidence that psychiatry puts forward in support of the claim that mental disorders have an important genetic basis and the reasons why psychiatry is still searching after many decades of failed attempts.

Schizophrenia Twin Research as Reported in The Gene: An Intimate History...

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In his 2016 book The Gene: An Intimate History, cancer physician and researcher Siddhartha Mukherjee chronicled the initial idea of the gene, taking readers through the history of genetics up to the current “post-genome” period by interweaving science, social history, and his own personal narrative. In the process he documented some of the crimes of the eugenics movement and the monstrous atrocities committed by German National Socialism in the name of eugenics and biology, while noting the Nazi’s promotion of twin research. He also criticized aspects of intelligence testing and genetic theories of racial inferiority based on IQ tests. At the same time, Mukherjee supported and promoted many contemporary behavioral genetics positions.

Twin Method Assumptions are Indefensible, but are Useful to the Rich...

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The wealthy, and the institutions they finance and promote, look favorably upon research whose authors claim that economic disparities are rooted in biology, and are not harmful to humanity as a whole. But there are countless obvious real-world examples showing that political policies, social struggles, and public health programs, including those involving the adjustment of income differences, lead to improved health and well-being.

“There are no ‘Schizophrenia Genes’: Here’s Why”

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Richard Bentall and David Pilgrim offer their critique of genetic theories of schizophrenia for the Conversation. "The high heritability estimates reported in earlier quantitative...

Comments on Jeffrey Lieberman and Ogi Ogas’ Wall Street Journal Article...

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The March 3rd, 2016 edition of the Wall Street Journal featured an article by past President of the American Psychiatric Association (APA) Jeffrey Lieberman and his colleague, computational neuroscientist Ogi Ogas. The article was entitled “Genetics and Mental Illness—Let’s Not Get Carried Away.” In their piece, the authors started by expressing the belief that a recent study identified a gene that causes schizophrenia, and then discussed whether it is desirable or possible to remove allegedly pathological genes in the interest of creating a future “mentally perfect society.” The authors of the article, like many previous textbook authors, seem unfamiliar with the questionable “evidence” put forward by psychiatry as proof that its disorders are “highly heritable” In fact, DSM-5 Task Force Chair David Kupfer admitted that “we’re still waiting” for the discovery of “biological and genetic markers” for psychiatric disorders.

“Mental Illness and Familial Influences”

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"Let us be clear that claims about established genetic or biochemical causation for mental distress are, as things stand, entirely fictional," writes Dr Lucy...

“Bewitching Science” Revisited: Tales of Reunited Twins and the Genetics...

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In this article I will attempt to debunk one of the great “scientific” smoke and mirrors shows of the past half century—the claim that stories of reunited separated MZ (monozygotic, identical) twin pairs indicate that heredity plays a major role in causing human behavioral differences. These stories, which are often used to sell the false ideology of genetic determinism, have entered the public imagination in a way that academic research results never could. Here I will show that these stories provide no evidence whatsoever that (as yet undiscovered) “genes for behavior” influence human behavioral development.

All in the Brain? An Open Letter Re: Stephen Fry’s Assumptions...

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Stephen Fry’s exploration of manic depression (in the current BBC series on mental health, ‘In the Mind‘) has drawn both praise (because of his attempts to destigmatize mental illness) and criticism (because he appears to have a very narrow biomedical understanding of mental illness).  I have sent an open letter to the actor which challenges some of his assumptions about mental illness, and offers a very different understanding to that promoted in his recent television programme.

“Schizophrenia Breakthrough” – Or a Case of Ignoring the Most Important...

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Last week, the headlines blared: "Schizophrenia breakthrough as genetic study reveals link to brain changes!"  We heard that our best hope for treating “schizophrenia” is to understand it at a genetic level, and that this new breakthrough would get us really started on that mission, as it showed how a genetic variation could lead to the more intense pruning of brain connections, which is often seen in those diagnosed with schizophrenia.  “For the first time, the origin of schizophrenia is no longer a complete black box,” said one (while admitting that "it's still early days").  The acting director of the National Institute of Mental Health (NIMH) described the study as “a crucial turning point in the fight against mental illness.” But is all this hype justified?

And Now for Something Completely the Same:  The Latest, Greatest Breakthrough...

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Another scientific study that ostensibly identifies a biological cause of schizophrenia has appeared and is being widely reported. So, we finally have the elusive breakthrough to understanding the biological basis of schizophrenia. Or do we? A close look at the source of all this hyperbolic language raises serious questions about such enthusiasm.

Breaking News! The Cause of Schizophrenia Finally Discovered!(?)

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On January 27, 2016, a study1 was published online in the prestigious journal Nature that touted the possibility of discovering some potential biological origins of an "illness" called "schizophrenia" Subsequently, headlines across the world beamed excited proclamations of the latest breakthrough to occur in psychiatric research. The problem is, there is nothing profound about this study at all and, in fact, it is one of the least profound studies to emerge in the last few years on the topic of "schizophrenia." It ignores the robust support that has accumulated that undermines the genetic disease model of "mental illness" and the categorical understanding of experiences falling under the umbrella term "schizophrenia."

The Genetics of Schizophrenia: A Left Brain Theory about a Right...

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In recent months, two teams of researchers in the UK and the US published complementary findings about the epigenetic origins of schizophrenia that have scientific communities who indulge in ‘genetic conspiracy theories’ abuzz. While these results are intriguing, and no doubt involve pathbreaking research methodologies, this line of thought represents a decontextualized understanding both of the symptoms that are typically associated with schizophrenia, and their causes.