Tag: genetics of schizophrenia
The “genetics of mental disorders” story told in Kolker's "Hidden Valley Road" involves omission and misrepresentation of genetic research.
The time has come to halt the massive failure that has characterized schizophrenia molecular genetic research, and to thoroughly reassess what critics have always said are the severely flawed family, twin, and adoption studies that inspired and helped justify this research.
In his 2016 book The Gene: An Intimate History, cancer physician and researcher Siddhartha Mukherjee chronicled the initial idea of the gene, taking readers through the history of genetics up to the current “post-genome” period by interweaving science, social history, and his own personal narrative. In the process he documented some of the crimes of the eugenics movement and the monstrous atrocities committed by German National Socialism in the name of eugenics and biology, while noting the Nazi’s promotion of twin research. He also criticized aspects of intelligence testing and genetic theories of racial inferiority based on IQ tests. At the same time, Mukherjee supported and promoted many contemporary behavioral genetics positions.
The wealthy, and the institutions they finance and promote, look favorably upon research whose authors claim that economic disparities are rooted in biology, and are not harmful to humanity as a whole. But there are countless obvious real-world examples showing that political policies, social struggles, and public health programs, including those involving the adjustment of income differences, lead to improved health and well-being.
The March 3rd, 2016 edition of the Wall Street Journal featured an article by past President of the American Psychiatric Association (APA) Jeffrey Lieberman and his colleague, computational neuroscientist Ogi Ogas. The article was entitled “Genetics and Mental Illness—Let’s Not Get Carried Away.” In their piece, the authors started by expressing the belief that a recent study identified a gene that causes schizophrenia, and then discussed whether it is desirable or possible to remove allegedly pathological genes in the interest of creating a future “mentally perfect society.” The authors of the article, like many previous textbook authors, seem unfamiliar with the questionable “evidence” put forward by psychiatry as proof that its disorders are “highly heritable” In fact, DSM-5 Task Force Chair David Kupfer admitted that “we’re still waiting” for the discovery of “biological and genetic markers” for psychiatric disorders.
In this article I will attempt to debunk one of the great “scientific” smoke and mirrors shows of the past half century—the claim that stories of reunited separated MZ (monozygotic, identical) twin pairs indicate that heredity plays a major role in causing human behavioral differences. These stories, which are often used to sell the false ideology of genetic determinism, have entered the public imagination in a way that academic research results never could. Here I will show that these stories provide no evidence whatsoever that (as yet undiscovered) “genes for behavior” influence human behavioral development.
Last week, the headlines blared: "Schizophrenia breakthrough as genetic study reveals link to brain changes!" We heard that our best hope for treating “schizophrenia” is to understand it at a genetic level, and that this new breakthrough would get us really started on that mission, as it showed how a genetic variation could lead to the more intense pruning of brain connections, which is often seen in those diagnosed with schizophrenia. “For the first time, the origin of schizophrenia is no longer a complete black box,” said one (while admitting that "it's still early days"). The acting director of the National Institute of Mental Health (NIMH) described the study as “a crucial turning point in the fight against mental illness.” But is all this hype justified?
Another scientific study that ostensibly identifies a biological cause of schizophrenia has appeared and is being widely reported. So, we finally have the elusive breakthrough to understanding the biological basis of schizophrenia. Or do we? A close look at the source of all this hyperbolic language raises serious questions about such enthusiasm.
On January 27, 2016, a study1 was published online in the prestigious journal Nature that touted the possibility of discovering some potential biological origins of an "illness" called "schizophrenia" Subsequently, headlines across the world beamed excited proclamations of the latest breakthrough to occur in psychiatric research. The problem is, there is nothing profound about this study at all and, in fact, it is one of the least profound studies to emerge in the last few years on the topic of "schizophrenia." It ignores the robust support that has accumulated that undermines the genetic disease model of "mental illness" and the categorical understanding of experiences falling under the umbrella term "schizophrenia."
“The substantial hereditary component in schizophrenia,” a pair of researchers wrote in 1993, “is surely one of the two or three best-established facts in psychiatry.” But is it really? For mainstream psychiatry and psychiatric genetics, schizophrenia is “a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%,” or a “highly heritable neuropsychiatric disorder of complex genetic etiology.” Many commentators have challenged these claims, and some have challenged the concept of schizophrenia itself.