Antidepressants, Not Depression, Raise Risk of Preeclampsia in Pregnancy

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In a study of 69,448 pregnant women with depression, researchers from the Harvard school of public health found that use of SSRI (selective serotonin reuptake inhibitors) during pregnancy were associated with a 1.22% greater chance of preeclampsia, SNRI (selective norepinephrine reuptake inhibitors) with a 1.95% greater chance, and TCA (tricyclic antidepressants) with a 3.23% greater chance. If the women had used these drugs prior to pregnancy, the chances of preeclampsia rose to 1.32%, 3.43%, and 3.26% respectively. Results will appear in the American Journal of Epidemiology.

Abstract → 

Palmsten, K. Setoguchi, S. et al; “Elevated Risk of Preeclampsia in Pregnant Women With Depression: Depression or Antidepressants?American Journal of Epidemiology, 175(10) 988-997

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University as well as an MFT degree from the Council for Relationships in Philadelphia. Kermit leads workshops and webinars on the role of humor in psychotherapy and other human services. You can reach him at [email protected].

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