Genetics of Bipolar Disorder


Research from the Semel Institute for Neuroscience and Human Behavior at USC finds that “The standard concept of genetic testing includes at least three broad criteria that need to be fulfilled before new genetic tests should be introduced: analytical validity, clinical validity, and clinical utility. These criteria are currently not fulfilled for common genomic variants in psychiatric disorders.”

Article (available for download) →

Kerner, B., Genetics of Bipolar Disorder. The Application of Clinical Genetics. February 2014,  volume 7: 22-42. DOI:

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].


  1. Some things never change. Here is a review of Pseudoscience in Biological Psychiatry exposing the same decades old junk science eugenics agenda to find what Dr. Jay Joseph calls The Missing Gene or The Gene Illusion to expose the fraud of the never ending search for genes for bogus, voted in DSM stigmas like the latest bipolar fad fraud to push the most lethal, lucrative drugs:

    Dr. Colin Ross explains that even if some supposed genes were found for bogus schizophrenia, some people could have the supposed genes and none of the symptoms. Of course, he is assuming that biopsychiatry would be ethical and admit no treatment was necessary when in fact, many predatory biopsychiatrists today are fighting for “preventive treatment” based on similar bogus assumptions that the “mental illness genes” can be corrected with poison drugs or the latest brain/body damaging “treatment.”

    Many articles have been posted on MIA that have exposed the current eugenics of biopsychiatry is very similar to that of the Nazi Germany era whereby the robber barons then and now seek such bogus eugenics claims to justify their theft of the world’s wealth while enslaving the majority and their desire to cull the world’s population for easier fascist control. These same articles expose that despite billions of dollars wasted on this never ending bogus search for the missing genes to prove the inferiority of the poor, non-whites and other targeted groups, all the evidence points to the truth that no such genes have been found because there aren’t any to find since all the emotional and other distress in certain social groups are due to unjust social/environmental causes. Dr. Jay Joseph has exposed this truth in his great works too. Just think if the billions wasted on the biopsychiatry/Big Pharma predatory agenda had been spent on affordable housing, healthy food, good schools, parks/playground and other necessities for children and families. The thought of this never ending predatory nightmare by the psychopathic power elite per book and web site Political Ponerology at tax payer expense no less makes me literally SICK!! DISGUSTED!! We should be checking out their genes and brains as does Dr. Robert Hare, world authority on psychopaths and author of Without Conscience and Snakes In Suits based on the classic work of Dr. Hervey Cleckley, author of The Mask of Sanity.

    This article is somewhat positive in that the requirements stated here may delay the ultimate con job and lies about the latest eugenics bipolar fraud claims, but the fact these disease mongers are chafing at the bit with the gleeful hope they will find such destructive genes again show they have no decency, empathy, compassion or humanity. It is similar to a doctor doing tests for cancer on patients and hoping to find cancer in stage four with the hope of not only gleefully sharing this horrible news but happy to make a great profit at the victim’s expense. Given the state of main stream medicine, I suppose that does happen at times especially given the so called treatment for many cancer false positives that do far more harm than good, which makes one want to avoid the whole medical industrial complex like the plague it has become.

    The fact that biopsychiatry is so determined to find these supposed missing genes and thrilled at the prospect of using these findings to prey on the rest of us shows those pursuing such an agenda that has already wasted billions that could have helped the real problems of their victims have no empathy, compassion or humanity.

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    • “all the emotional and other distress in certain social groups are due to unjust social/environmental causes”

      It looks like there may actually be some genetic connections here, but not only is there no money in it for Big Pharma, but one of its other cash cows, cancer, could also be put at risk. Investigate the work of Abram Hoffer, John Smythies and David Horrobin and the “adrenochrome theory of schizophrenia”. Smythies found that some people lack a functioning gene for Glutathione S Transferese, which detoxifies adrenochrome, a naturally produced hallucinogen. In the absence of any “unjust social/environmental causes” such people can live happy, productive lives, but if the “fight or flight” response is repeatedly provoked in them, they can become psychotic.

      And what about individuals who have a functioning gene for Glutathione S Transferese? What happens to them when they encounter “unjust social/environmental causes”? They don’t freak out on their self-made psychedelic adrenochrome, but they don’t benefit from adrenochrome’s cancer-protective qualities either.

      Alopathic medicine has also ignored an inexpensive and accurate test that can distinguish between these two genetic types. If one lacks the gene for Glutathione S. Transferese, one will not exhibit a skin flush shortly after taking a strong dose of niacin. Hoffer found that the majority of patients hospitalized for chronic schizophrenia showed no flushing. Horrobin confirmed this independently.

      Abram Hoffer was demonized by alopathic medicine for enabling thousands to have remission from schizophrenia, but what is not generally known, and earned him even more ire from the establishment is the great success he had with cancer patients.

      Learn more here

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      • Subvet416,

        Though your comment sounds very convincing, I must say I am not convinced because if there was such a gene in so called schizophrenic or bipolar people, I believe biopsychiatry would have pounced on said gene to push their multibillion dollar neuroleptics and other lethal treatments and use it to validate that they are dealing with real diseases as they claim all the time with no evidence. If you check out the link to the book I cited above, Pseudoscience in Biological Psychiatry, they have been searching for such genes for decades and despite countless fraudulent lies that they have found such genes based on bogus twin and other studies that have been debunked by experts, they have had to admit when outed time after time that no such genes exist though they are supposedly always on the verge of finding them to waste more billions of our tax and other money. Dr. Jay Joseph and many other experts in the field have confirmed very recently that there are very few genes connected with any illnesses since most come about due to life style choices, toxins in the environment and other environmental factors including poverty, injustice, prejudice, inequality and other crucial factors. So, to avoid dealing with the real problems, our dear government and the power elite uses biopsychiatry to blame the victims and promote social control for our current fascist therapeutic state. See above review of the book, Pseudoscience… about how supposed biological misfortune is used to rob citizens of all their rights in the guise of “mental health” since they couldn’t get away with it so easily otherwise in a supposed democracy.

        Plus, DSM stigmas like schizophrenia and bipolar are bogus and are applied to a ridiculously diverse number of people. For example, a psychiatrist blogging on MIA admitted that rape victims (like domestic violence/bullying/mobbing victims) are routinely stigmatized as bipolar. This fraud, which has been greatly criticized by experts like Dr. Carole Warshaw, psychiatrist and domestic violence expert, as very damaging since such abuse often causes trauma and such bipolar stigmas aid and abet the abusers. To add insult to injury, Gary Sampson, serial killer, in the news lately has also been “diagnosed” with bipolar disorder!! What a farce!!

        Dr. Mary Boyle wrote a book, Schizophrenia: A Scientific Delusion? cited in the above Pseudoscience… book. Most psychiatrists admit that schizophrenia covers a huge number of very different presentations leading many to believe it is many “illnesses” or problems and not just one. And often people are falsely accused of being delusional or psychotic because they don’t agree with the biopsychiatrist or a more powerful abuser or bully uses biopsychiatry to destroy his/her victims. See the great movie, Gaslight, with Ingrid Bergman and Charles Boyer to see how this is done! So, how can one find genes for something that is applied in such a ridiculous, predatory fashion to stigmatize and drug as many as possible for maximum profits with little commonality among the stigmatized? You can’t, but a rule of manipulation is if something is repeated often enough, people will come to believe it. Hitler and his cohorts in crime knew this human tendency all too well as does biopsychiatry since their bogus, vicious eugenics theories were the main cause of most human holocausts in recent history!

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  2. I read the article and I can’t make head or tails out of it. I wish someone in the MIA community who has a scientific background would interpret this article for me. I don’t have time to run to the dictionary every five seconds.

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    • As a person with a scientific background (BS in Chemistry, plus lots of familiarity with social science research), it really isn’t that hard to interpret, once you sift through the BS. The main reason you are having a hard time understanding it, besides the use of intentionally technical language to make it look like they know what they’re talking about, is because most of it really doesn’t make sense.

      The following lines sum it up:

      “After all, common variants explain only a very small percentage of the genetic risk, and functional consequences of the discovered SNPs are inconclusive. Furthermore, the associated SNPs are not disease specific, and the majority of individuals with a “risk” allele are healthy.”

      Translation: most of the people who have “bipolar disorder” don’t have these genetic markers (“very small part of the genetic risk”), even for those who do have the markers, we don’t really know if “bipolar disorder” or anything specific will result (“functional consequences of the discovered SNPs are inconclusive”), some people with other “mental health disorders” have exactly the same markers (“not disease specific”), and most people who have these “risk” markers don’t have anything wrong with them at all (“the majority of individuals with a risk allele are healthy).

      Or to sum up: We’ve discovered a genetic marker that is more likely to be present in “bipolar” clients than in healthy ones. However, the vast majority of people who have a “bipolar” diagnosis don’t have the marker, lots of people who have the marker have something else wrong with them besides “bipolar,” and most of the people with the marker have nothing wrong with them at all.

      It’s a pretty lame effort – “grasping at straws” doesn’t even sum it up. They are desperate to find some correlations with genes, but if this were of significance, we’d find that 1) most people with “bipolar” diagnoses have this variant; 2) most people who have the variant have a “bipolar” diagnosis, and 3) the vast majority of healthy people don’t have this variant at all. They’re 0 for 3 in my book.

      — Steve

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