There’s Little Evidence Abuse-Deterrent Opioids Work

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FromĀ STAT: In recent years, the pharmaceutical industry has proposed using abuse-deterrent opioids – those that make it more difficult to crush, snort, or inject the underlying opioid – as a way to address the opioid epidemic. However, there is almost no real-world evidence that abuse-deterrent opioids actually decrease opioid misuse; mandating coverage of these medications could be a tremendous waste of resources.

“Even if the evidence isnā€™t compelling that these products result in lower rates of opioid abuse, why not support them on the possibility that they might help, even if just a little? For the precise reason that the pharmaceutical industry is so interested in mandating the use of these products: They are far more expensive than generic opioids.

We compared the best retail price for three approved abuse-deterrent morphine products ā€” Embeda, MorphaBond, and Arymo ER ā€” against the price of generic extended-release morphine, using the same dose (30 milligrams) and supply (60 pills) for each. The best retail price for the generic morphine is $43.82 for a monthā€™s supply, while the best prices for the other three products range from $567.78 to $1,013.03 for a comparable supply.”

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