Saturday, November 27, 2021

Researchers Push to End Placebo Run-in Periods in Antidepressant Studies

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Meta-analysis finds that the placebo run-in methodology reduces the placebo effect and finds antidepressants to be less useful.

Withdrawal Symptoms Cloud Findings of Antidepressant “Relapse” Trial

3
Leading researchers point out that a new antidepressant study in NEJM failed to account for withdrawal symptoms, casting doubt on the results.

Researchers Provide Guidance for Reducing and Stopping Psychiatric Drugs

27
New guidance on how to taper and discontinue from psychiatric drugs from leading researchers Mark Horowitz and David Taylor.

Manufacturer of Tardive Dyskinesia (TD) Drugs Finds TD Emotionally Devastating

12
“Patients expressed feeling unaccepted by society or uncomfortable in their own skin… A few indicated that they would rather be dead than have tardive dyskinesia.”

Antipsychotics Linked to Increased Breast Cancer Risk

0
Long-term exposure to prolactin-increasing antipsychotics increases the odds of developing breast cancer.

New Rating Tool for Tapering Antidepressants and Antipsychotics

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Researchers developed a rating scale to better assess service users’ experiences tapering antidepressant and/or antipsychotic medication.

Antipsychotics Increase Risk of Dementia; New Research Illuminates Why

15
In JAMA psychiatry, researchers outline new theories connecting antipsychotic use in people with schizophrenia and increased dementia risk.

Newborn Babies Go Through Antidepressant Withdrawal

2
A new study finds that newborn babies experience antidepressant withdrawal after birth if their mothers take SSRIs when pregnant.

Psychiatric Drugs may Reduce Social and Emotional Capacities

7
Research finds that social cognition and emotional processing abilities can be disrupted by psychiatric drugs.

Tapered Antipsychotic Withdrawal Mitigates Risk of Psychotic Symptoms

15
Research suggests that slowly tapering off an antipsychotic reduces the risk of withdrawal psychosis compared to abrupt discontinuation.

“Relapse” in Antidepressant Trials Likely Caused by Sudden Withdrawal

3
A new study investigates how antidepressant withdrawal effects often get confounded with depression relapse in clinical trials.

Sudden Antipsychotic Withdrawal—Not Low Dose—Leads to Relapse

13
A new article in Lancet Psychiatry debunks past studies claiming that those on low doses of antipsychotics are more likely to relapse.

Lead Exposure in Childhood Impacts Personality and Mental Health

3
A study of over 1.5 million people in Europe and the US links the development of less adaptive personalities with childhood lead exposure.

Antipsychotic Adherence Research Overlooks Key Information

17
Researchers argue for a shift away from a focus on antipsychotic adherence toward understanding service users’ diverse patterns of use.
Question mark inside a maze in the shape of human head.

New Study: The Clinical High Risk for Psychosis (CHR-P) Model Is Flawed

3
The CHR-P model focuses on “attenuated psychosis” to predict “transition” to schizophrenia and ignores other factors. But new research shows that the model is a poor predictor.

Researchers Propose Study to Test Whether Antidepressants Impede Recovery

14
Evolutionary theorists suggest that antidepressants interfere with the adaptive function of depression and propose a test of this theory.

Pets More Effective for Grief Support than Humans, Study Finds

10
A new study explores effective forms of grief support, finding that animals are more effective than humans in providing support.
Doctor and patient

Barriers to Shared Decision Making in the Prescription of Antipsychotics

26
Researchers push for a renewed focus on true shared decision-making for patients diagnosed with psychosis.

No, the FDA’s Black Box Warning Did not Increase Suicides

8
Researchers again debunk the claim that the FDA black box warnings on antidepressants led to more suicides.

Minimal Medication Alternatives for Psychosis Needed

4
Researchers question the long-term use of antipsychotics and suggest increased research and investment in psychosocial interventions.

Psychotherapy Can Prevent Relapse When Discontinuing Antidepressants

15
“Short and simple psychological programs can prevent people from relapsing when they stop their antidepressants.”

Responsibility Without Blame in Therapeutic Communities: Interview with Philosopher Hanna Pickard

14
Hanna Pickard on the elusive middle ground between personal responsibility and systemic factors in our understandings of addiction.

Allen Frances Takes on the Over-Prescription of Antidepressants

16
The prominent psychiatrist explores why antidepressants remain highly overprescribed and offers solutions to the problem.

Anticholinergic Medications Linked to Cognitive Impairment in Schizophrenia

3
Researchers have found further evidence that the anticholinergic effect of psychiatric drugs can lead to cognitive impairments.

Ethical Issues Raised Over FDA Collaboration with Biogen on Failed Drug

7
The FDA collaborated with Biogen to conduct repeated re-analyses of aducanumab for Alzheimer's and FDA committee members are raising concerns.

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