Living Alone Nearly Doubles Antidepressant Use

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Finnish researchers found that in a study of 3471 men and women, those living alone were almost twice as likely to use an antidepressant....

Spontaneous Improvement in Depression, With and Without Placebo

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Researchers at Columbia University and Queens College reviewed 10 trials of antidepressants that used wait-listed controls in order to determine the contribution of spontaneous...

Mother Sues Pfizer for Alleged Zoloft-Related Birth Defects

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The latest in a series of Zoloft-related birth defect lawsuits was filed in St. Louis yesterday, by a firm that claims to represent hundreds...

Women on SSRIs Less Likely To Breastfeed

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In a prospective cohort study of 466 pregnant women over 10 years, researchers at the California Teratogen Information Service found that women exposed to...

Increased Expectancy Explains Improved Response in Antidepressant Trials

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The Vermont Longitudinal Study & Correction of Seven Myths

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In a long-term study of schizophrenia patients released during the late 1950s and early 1960s from the back wards of Vermont State Hospital, Courtenay...

Brain Volume Recovers With Remission, Not With Medication

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In a prospective study of 28 outpatients with major depression, Canadian researchers investigated whether brain volume changes stabilized with antidepressant treatment and/or reversed with...

The Antidepressant Solution

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Book by Joseph Glenmullen, a "Step-by-Step Guide to Safely Overcoming Antidepressant Withdrawal, Dependence and 'Addiction.'" Go to Amazon                ...

Why Is It So Difficult to Stop Psychiatric Drug Treatment?

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Joanna Moncrieff's 2006 paper in Medical Hypotheses discusses the possibility that the research on maintenance and discontinuation of medication is flawed because it fails...

No Evidence For Antidepressants in Depression With Dementia

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In a review and meta-analysis of double-blind, placebo-controlled, randomly-assigned trials of antidepressants marketed in the U.S., researchers at the University of California failed to...

Adolescents at Risk for Psychosis Do Worse On Antipsychotics

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In a study of 53 adolescents at risk for psychosis, researchers from Canada and the U.S. looked at treatment with antidepressants, antipsychotics, and no...

SSRIs Cause Delayed Head Growth and Premature Birth

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In a study of 7,696 pregnant women, researchers in the Netherlands and the U.S. found that SSRIs caused slower head growth and premature birth....

Antidepressant Use Associated with Brain Atrophy and Lesions in Elderly

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In a study of 630 elderly Manhattanites without dementia, researchers from the Netherlands found that antidepressant use was associated with significantly more brain atrophy,...

Antidepressant Use and Cognitive Impairment After Menopause

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A study of 6,998 postmenopausal women followed over 7.5 years found that antidepressant use correlated with a 70% increased risk of cognitive impairment. The...

Serotonin and Depression: A Disconnect Between the Advertisements and the Scientific Literature

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MIA bloggers Jonathan Leo and Jeffrey Lacasse review the Serotonin Hypothesis as represented in advertising and as verified in scientific literature, finding a disturbing...

Cumulative Risk of Impairment and Death From Anticholinergic Medication

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The New York Times reports that a two-year longitudinal study of over 13,000 men and women over 65 found that anticholinergic medications, which include many...

Better Recovery and Less Relapse Without Meds: A 20-Year Study

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Researchers at the University of Illinois College of Medicine found, in a 20-year prospective study of 139 psychotic patients, that patients had a far...

60 Minutes to Cover Antidepressant/Placebo Controversy This Sunday

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Lesley Stahl interviews Irving Kirsch of the Placebo Studies Program at Harvard Medical School this Sunday's edition of 60 Minutes. Stahl says the implication...

Antidepressants Have No Effect On Bipolar Depression

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In a review of 68 articles published between 2005 and 2011, Israeli researchers found that most well-controlled studies failed to show a significant effect of...

David Healy Critiques Gibbons’ Reanalysis of Antidepressants and Suicide

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David Healy critiques the reanalysis by Robert Gibbons of antidepressants and suicidality in children and adolescents that was reported on this page yesterday. He...

Suicidal Thoughts and Behavior With Antidepressant Treatment: A Reanalysis

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In 2004 and 2006, the FDA concluded that SSRI antidepressants increased the risk of suicidal ideation in children and adolescents. However, in this month's...

Lawsuit Filed for Alleged Zoloft-Related Birth Defects

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Lawyers in St. Louis have filed a lawsuit against Pfizer that alleges 18 children were born with birth defects caused by the antidepressant Zoloft...

Bribery Alleged in Largest Antidepressant Study Ever Conducted

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A 2011 whistleblower complaint that was unsealed on January 20 of this year alleges that Forest Pharmaceuticals bribed a principle investigator of the STAR*D...

Antidepressants Increase Suicide Risk in Children and Adolescents

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In a meta-analysis of studies of 6039 individuals, researchers in the UK determined that, consistent with previous meta-analysses, antidepressants increased "suicide-related outcomes."  Read more    ...

Discontinuing Psychotropics Reduces Falls in Elderly

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Australian researchers look at the literature on the effect of psychotropics on falls in the elderly; largest effect of any randomized trial was achieved...