SSRIs Increase Post-Surgical Complications

A study of 530,000 patients who underwent surgery at 375 U.S. hospitals found a 10% increased risk of post-operative complications including bleeding, transfusion, hospital...

Could ‘Treatment Resistance’ be an Effect of Antidepressants?

Previously taking antidepressants could make individuals less likely to respond to treatment for bipolar II depression.

The Issue of Over-Diagnosing in Psychiatry

From The Concordian: On October 30th, Dr. Joel Paris, a professor of psychiatry at McGill University, gave a lecture about the dangers and consequences of...

“When Pills Are the Problem”

In the context of the Silicon Valley suicides, one mother offers her story about her daughter. “It’s my premise that not only the culture of Silicon Valley, but also, almost more importantly, the nature of the remedies that are being proposed in the name of mental health counseling, are to blame in these deaths.”

Unpublished Trials Reveal Antidepressant Provides Little Benefit For Depression or Anxiety

Upon reviewing all of GlaxoSmithKline's data from both published and unpublished trials of the antidepressant paroxetine, researchers found the drug provided almost no benefits...

High Doses of Antidepressants Increase Self-Harm in Children, Young Adults

A comprehensive meta-analysis of randomized trial data by researchers from the Harvard School of Public Health finds that children and young adults who start...

Journal Chooses Not to Retract “Misleading” Paxil Study Despite Criminal Conviction

The Journal of the American Academy of Child and Adolescent Psychiatry has chosen not to retract Martin Keller's study of Paxil in children ("Study...

Scientists Clarify Risks of Augmenting with Antipsychotic Medications for Depression

The researchers found that while antipsychotic drugs may be slightly more effective than alternative antidepressants, they come with a much higher side effect burden.

Psych Meds Found in the Home of Woman Killed in D.C. Car Chase

Miriam Carey, who was shot and killed yesterday by D.C. police after she attempted to drive through a White House barricade with her 1-year-old...

SNRIs Added to the List of Drugs with Potential Withdrawal Symptoms

New research suggests that clinicians should exercise caution prescribing SNRIs as first-line treatment for mood and anxiety disorders.

My Drug Dealer Was a Doctor: A Story of Withdrawal

In this piece for Medium, Michael E. Lee tells his story of experiencing the horrific withdrawal effects of Effexor, and how he healed from his...

Massive Number of Antidepressant Meta-Analyses Biased By Industry

A massive number of meta-analyses of antidepressant clinical trials have financial conflicts of interest and are unduly influenced by pharmaceutical companies, according to a review to be published in an upcoming issue of the Journal of Clinical Epidemiology. Researchers also found that meta-analyses with industry ties almost never report any negative findings in their abstracts.

Antidepressants Linked to Risk of Adult-Onset Diabetes

A meta-analysis of studies of 168,435 adults who were free of diabetes at baseline found that those who used antidepressant medication were 68% more...

SSRI Exposure in Pregnancy Alters Fetal Neurodevelopment

Alterations in gray matter and white matter development found in infants of mothers taking SSRI antidepressants during pregnancy.

GlaxoSmithKline Accused of Hiding Paroxetine Results

The UK Times reports that pharmaceutical companies are actively lobbying to limit the release of clinical trial data to the public. Rather than limiting results and data to medical journals, new transparency initiatives are pushing for making the information publically available. The push for transparency comes in the wake of the reanalysis of the Study 329 data on paroxetine (marketed as Seroxat and Paxil), which found that the industry study had misconstrued its results.

“Controversial Paxil Paper Still Under Fire 13 Years Later”

From Wednesday's Brown Daily Herald: "Two weeks ago, Edmund Levin and George Stewart, members of the American Academy of Child and Adolescent Psychiatry, sent...

SSRI Does Not Improve Outcomes or Mood for Patients with Heart Failure

A study released this week in JAMA examined whether giving patients with chronic heart failure and depression the SSRI antidepressant escitalopram (Lexapro) for two...

Podcast: The Top 10 Quotes of 2017

In this podcast for, Michael Joyce shares what he considers the 10 most compelling quotes from last year's podcast episodes. The quotes include a wide variety...

A Brief History of Prozac

Prozac, having failed as an antihypertensive then anti-obesity drug, was marketed as an antidepressant after it lifted the spirits of five mildly depressed volunteers...

A New Silver Bullet? The Lurasidone Story

Recently, I have been the target of much wooing by my local Sunovion rep. I think he leaves messages for me almost weekly and he sends me missives - glossy brochures and reprints from major psychiatric journal. What is the subject of this attention? The drug - lurasidone (Latuda).

The Truth About Long-Term Antidepressant Use

From The Guardian: As antidepressant prescriptions rise and have doubled in the past decade, mental health experts are becoming increasingly concerned about adverse effects and...

Challenging the Relentless Rise of Depression in Young People

In this piece, Dave Traxson discusses the social and cultural factors contributing to the rise of depression among young people in Britain, arguing that...

After the Black-Box: Majority of Children Starting SSRIs Still Receiving Too High of Dose

In 2004, the FDA added a black-box warning to SSRI antidepressants on the increased risk of suicide among children taking these drugs. A new study suggests that this warning has increased the proportion of children who begin an antidepressant on a low dose, but the majority are still receiving higher than recommended doses.

Continuing the Antidepressant Debate: the Clinical Relevance of Drug-Placebo Differences

German psychiatrist Stefan Leucht and colleagues have produced another really important paper. The results indicate that the small differences usually found between antidepressants and placebo are far below the sort of differences that would be clinically detectable or meaningful. Leucht et al. have conducted the first thorough, systematic attempt to provide some empirical evidence about what constitutes a clinically meaningful difference in scores on depression rating scales, although the study did not set out to explore antidepressant effects.

One in Seven Scots Take Antidepressants

Following a fourfold-increase in antidepressant use in Scotland over the last two decades, one in seven Scots are taking the drugs.  Prescriptions for antipsychotics...