A study in Urology found that men receiving Zoloft for treatment of premature ejaculation had a significant reduction in sperm concentration and significant increase of DNA fragmentation in their sperm, compared with men receiving behavioral therapy for the condition, who exhibited no changes. “Although in recent years the use of medication in many psychiatric disorders has become quite common and acceptable, the importance of research on the harmful effects of these drugs should not be neglected,” the authors write.
Akasheh, G., Sirati, L., Kamran, Ali., Sepehrmanesh, Z., Comparison of the Effect of Sertraline With Behavioral Therapy on Semen Parameters in Men With Primary Premature Ejaculation. Urology. Online February 11, 2014.
SSRI May Negatively Affect Male Fertility (Medscape Medical News)