Zoloft Affects Sperm Qualities: May Affect Fertility


A study in Urology found that men receiving Zoloft for treatment of premature ejaculation had a significant reduction in sperm concentration and significant increase of DNA fragmentation in their sperm, compared with men receiving behavioral therapy for the condition, who exhibited no changes. “Although in recent years the use of medication in many psychiatric disorders has become quite common and acceptable, the importance of research on the harmful effects of these drugs should not be neglected,” the authors write.

Abstract →

Akasheh, G., Sirati, L., Kamran, Ali., Sepehrmanesh, Z., Comparison of the Effect of Sertraline With Behavioral Therapy on Semen Parameters in Men With Primary Premature Ejaculation. Urology. Online February 11, 2014.

SSRI May Negatively Affect Male Fertility (Medscape Medical News)

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].


  1. It strikes me that the “research on the harmful effects of these drugs,” the lack thereof has created sperm count issues and birth defects in babies, should have been done prior to these drugs being mass marketed to the American public. What a sick joke the greed only inspired psycho / pharmaceutical industries have made of the entire mainstream American medical community.

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  2. I get a kick out of those Big Pharma ads that warn, “Seek medical attention for any erection lasting more than four hours.” I wonder how many poor saps, hearing that, said “That’s for me!” and when warned about blindness as a possible side effect, said “I’ll just take it until I need glasses.”

    Any of you MadMen troubled by premature ejaculation (“two-stroking”) should try this old Submarine Force remedy. Grease the unruly torpedo with Nupercainal about an hour before battle stations. Then, when once aware of the possibilities produced by this improved performance, study Kundalini Yoga and the Kama Sutra.

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