Finnish reseachers report in Schizophrenia Research that antipsychotic use is associated with cognitive and memory impairments. The University of Oulu team studied forty people diagnosed with schizophrenia and 73 controls at the ages of 34 and 43 years. “Higher antipsychotic dose-years by baseline were significantly associated with poorer baseline performance in several dimensions of verbal learning and memory, and with a larger decrease in short-delay free recall during the follow-up,” they observed.
“The use of high doses of antipsychotics may be associated with a decrease in verbal learning and memory in schizophrenia years after illness onset,” the researchers concluded. “The results do not support the view that antipsychotics in general prevent cognitive decline or promote cognitive recovery in schizophrenia.”
Lifetime use of antipsychotic medication and its relation to change of verbal learning and memory in midlife schizophrenia — An observational 9-year follow-up study (Husa, Anja P. et al. Schizophrenia Research. Published Online: July 15, 2014. DOI: http://dx.doi.org/10.1016/j.schres.2014.06.035)