A retrospective study in the Journal of Clinical Psychiatry identified 183 possible cases of people who suffered sexual dysfunction that endured even after stopping taking SSRI antidepressants. Of these, the Israeli researchers identified “23 high-probability cases” of “Post-SSRI Sexual Dysfunction” (PSSD).
“Possible cases were subjects with normal pretreatment sexual function who first experienced sexual disturbances while using a single SSRI/SNRI, which did not resolve upon drug discontinuation for 1 month or longer,” wrote the researchers. “High-probability cases were also younger than 50-year-olds; did not have confounding medical conditions, medications, or drug use; and had normal scores on the Hospital Anxiety and Depression Scale.”
“Limitations of the study include retrospective design and selection and report biases that do not allow generalization or estimation of incidence,” noted the researchers. “However, our findings add to previous reports and support the existence of PSSD, which may not be fully explained by alternative nonpharmacological factors related to sexual dysfunction, including depression and anxiety.”
The website RxISK has been tracking cases of apparent post-SSRI sexual dysfunction.
Ben-Sheetrit, Joseph, Dov Aizenberg, Antonei B. Csoka, Abraham Weizman, and Haggai Hermesh. “Post-SSRI Sexual Dysfunction: Clinical Characterization and Preliminary Assessment of Contributory Factors and Dose-Response Relationship.” Journal of Clinical Psychopharmacology, March 2015, 1. doi:10.1097/JCP.0000000000000300. (Abstract)