Antipsychotic Use Linked to Increased Mortality Risk in Parkinson’s


Medscape Medical News reports on a presentation of findings at the International Parkinson and Movement Disorder Society 19th International Congress, that showed a doubling and tripling of the risk of dying within 6 months for people with Parkinson’s if they were taking antipsychotics.

Antipsychotic Use Increases Mortality in Parkinson’s (Medscape Medical News, June 23, 2015) (Full text with registration)

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    • Exactly. Parkinson’s disease is caused by the death of dopamine-producing cells and levodopa can slow down the symptoms by making the still remaining cells more efficient at making the molecule. Giving the drug that does the exact opposite, that is disrupt dopamine signalling is crazy. It only shows you that the “doctors” have no f***ing idea what they’re doing. This is criminal medical error right here. I’m really lacking words on that painful stupidity.

  1. Its not that complicated. The people in the drug treated group were dying earlier for the same reason that they were having psychotic episodes: Because they had more advanced disease. Psychotic symptoms are known to be a symptom of relatively advanced Parkinson’s, and Parkinson’s is a progressive, fatal disease.

    Maybe it would be good for MIA to host an article on how to interpret clinical trial data, and especially the limitations of observational data from non-randomized studies.

    • One question: do you know what signalling pathway is affected in Parkinson’s disease and what signalling pathway is targeted by anti-psychotics?


      It’s like giving a diabetic a bit of insulin and then stuffing him full of cake. Sure it will not only not help but render the guy deadly sick.

  2. Surprise, surprise. Given that “anti-psychotics” cause many symptoms which are similar to Parkinson’s disease and interfere with normal dopamine signalling (which is already disrupted in this disease) – how dense does one have to be to give these drug to these patients (or anyone at all for that matter).

    It’s appalling. These people are either to stupid and uneducated to be working in the field of medicine or simply evil and should be in prison for murder. Or both.