From Psychiatric Times:
Two psychiatrists write in the Psychiatric Times that the response of the STAR*D investigators to a reanalysis of STAR*D data by Ed Pigott and colleagues, which told of how the STAR*D investigators violated the protocol in various ways to inflate the reported remission rate, “remain entirely insufficient.”
They write:
It is our opinion that the importance of STAR*D and its ramifications for the field of psychiatry are too serious to be dismissed. STAR*D is too cited and used too often to justify current prescribing practices.
The esteem held by our field in the age of modern medicine rests on the validity of our scientific pursuits. The direction our field has historically taken too often followed the dictates of dogma rather than evidence. We should not continue to make this mistake.
Even beyond the academic realm, psychiatry has faced more scrutiny from the public than any other medical field. Some of this criticism has been unjustified, but much of it has been well earned. The best defense of our field in this arena seems to rest in holding ourselves to the highest standards of integrity.
Lastly, and most importantly, we have an ethical duty to our patients to take an honest look at the evidence derived from our research when making decisions that will impact their mental health. Our patients, our field, and our integrity demand a better explanation of what happened in STAR*D than what has thus been provided. Short of this, the best remaining course to take is a retraction.