Tag: genetic testing

Genetic testing may help reduce the length of time people experience the harmful effects of antidepressant drugs, but it is not helpful for predicting efficacy.

Direct-to-consumer (DTC) genetic testing has an “alarmingly high” 40% false-positive rate.

From STAT: Proove Biosciences, which sold dubious DNA tests to predict opioid addiction risk, has been placed into court-ordered receivership for restructuring and asset sale. Experts...

From STAT: Federal investigators recently searched Proove Biosciences, a genetic testing company that purports to determine an individual's likelihood of becoming addicted to opioids. Proove's genetic...

Drug-drug interactions can be extremely dangerous, even if the CYPs are genetically normal. The picture becomes even more grim if we take into account drug-gene interactions. Genetic testing for variants in the CYP enzyme system will definitely save lives.

In his 2016 book The Gene: An Intimate History, cancer physician and researcher Siddhartha Mukherjee chronicled the initial idea of the gene, taking readers through the history of genetics up to the current “post-genome” period by interweaving science, social history, and his own personal narrative. In the process he documented some of the crimes of the eugenics movement and the monstrous atrocities committed by German National Socialism in the name of eugenics and biology, while noting the Nazi’s promotion of twin research. He also criticized aspects of intelligence testing and genetic theories of racial inferiority based on IQ tests. At the same time, Mukherjee supported and promoted many contemporary behavioral genetics positions.

“The substantial hereditary component in schizophrenia,” a pair of researchers wrote in 1993, “is surely one of the two or three best-established facts in psychiatry.” But is it really? For mainstream psychiatry and psychiatric genetics, schizophrenia is “a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%,” or a “highly heritable neuropsychiatric disorder of complex genetic etiology.” Many commentators have challenged these claims, and some have challenged the concept of schizophrenia itself.

NBC News reports that "Genetic tests to identify the most effective psychiatry drugs are the hot new thing in the race to create personalized treatments based on people's DNA.” An investigation by the New England Center for Investigative Reporting, however, found that these new tests are based on small studies conducted by device manufacturers, and those with financial conflicts on interest.