Reduced brain volumes due to SSRI exposure in pregnancy was not explained by maternal depression alone.
Selective publication bias in top psychiatry journals was not explained by the quality of the studies, but by financial ties to pharma.
Researchers find that SSRIs increase suicide attempts up to age 24, and have no preventative effect at any age, even for those at high risk of suicide.
For those with severe depression, inpatient CBT was effective but the adding antidepressants did not improve treatment outcomes.
The initial study, which has been used to promote antidepressants, employed outcome switching to hide poor results.
Response and remission rates were the same in the drug versus placebo groups, and Lexapro increased suicidality sixfold.
Moncrieff et al. respond to the contradictory and, in some cases, false concerns raised by these critics of their serotonin review.
Genetic testing may help reduce the length of time people experience the harmful effects of antidepressant drugs, but it is not helpful for predicting efficacy.
World Psychiatry article challenges conventional antidepressant prescription practices.
A new Cochrane review details the lack of evidence for antidepressants in the treatment of chronic pain.
New research by Jim van Os and Peter Groot finds that using hyperbolic tapering to discontinue antidepressants reduces withdrawal effects.
Males taking antidepressants were at 100 times the risk of erectile dysfunction compared with the healthy population and more than three times the risk even after controlling for other variables.
Study reveals most patients are dissatisfied with prescribers' support when discontinuing antidepressants.
New study finds polypharmacy for 73% of older adults on antidepressants, with 56% at risk of harmful drug interactions.
New guidance for primary care doctors in the UK on antidepressant discontinuation acknowledges severe and long-lasting withdrawal symptoms.
Post-SSRI sexual dysfunction (PSSD) may be a common adverse effect of antidepressants. Researchers are now attempting to understand the neurobiology behind it.
A new study promotes the use of a standardized approach to antidepressant tapering.
Combining drugs and therapy also did not lead to better depression outcomes than therapy alone.
Also, male mice born to mothers with an immune response exhibited “autistic-like” behaviors, scientists report.
A new study in rats found that those exposed to antidepressants in utero had an impaired ability to nurture their own children in later life.
A new literature review reinforces the need to “down-titrate” or taper antidepressants, especially drugs like Celexa and Paxil.
Researchers suggest that antidepressant withdrawal can be a possible precipitant of suicide.
A study finds that commonly prescribed antidepressants are associated with the development of diabetes, hypertension, and other diseases.
Babies born to mothers taking antidepressants during pregnancy were more than six times as likely to have neonatal withdrawal syndrome—including breathing problems, irritability/agitation, tremors, feeding problems, and seizures—than those born to mothers taking other types of drugs.
Researchers can’t predict the 15% who benefit from antidepressants, and the other 85% are unnecessarily exposed to the harms of the drugs.