Sunday, July 21, 2019
A bottle of pills. Some are spilled out.

Antidepressant Use More Than Doubles Risk of Suicide Attempts

Throughout the past two decades, studies have warned of increased suicide rates in those taking antidepressants, especially in children and adolescents. Researchers also documented...

Anticholinergic Psychiatric Drugs Linked to a 50% Increase in Dementia

People who take anticholinergic drugs, such as antidepressants and antipsychotics, are at a 50% higher risk of dementia.

Researcher Critiques Misleading Claims About Antidepressants

Recent claims about antidepressant effectiveness have been based on misleading statements and misunderstandings of the science.

Exposure to Antidepressants in the Womb Linked to Autism

Researchers, publishing in Toxicology Research, review the evidence that antidepressant exposure in the womb is linked to autism spectrum disorders (ASD) in humans.

Exposure to Antidepressants in the Womb Linked to Autistic Behavior in Mice

Researchers experimenting on mice found that exposure to fluoxetine (Prozac) in utero resulted in behaviors considered in animal studies to be analogous to autism in humans.

Antidepressant Use Linked to Longer, More Frequent Psychiatric Rehospitalization

New study finds that antidepressants may negatively impact recovery after psychiatric hospitalization.

The Effects of Antidepressant Exposure Across Generations: An Interview with Dr. Vance Trudeau

Dr. Vance Trudeau discusses his study's finding that antidepressants may have far-reaching, adverse effects that last up to three generations.

Combining Mirtazapine with Existing SSRI or SNRI Does Not Improve Depressive Symptoms

Study finds combining mirtazapine with an SSRI or SNRI is not clinically effective for improving depression in primary care patients who remained depressed after taking an SSRI or SNRI.

New Study Finds Limited Effectiveness for Antidepressants After Stroke

The researchers found that although antidepressants had a slight short-term effect on reducing the likelihood of depression diagnosis, there was no long-term improvement, nor any improvement in motor functioning.

Researchers Challenge Interpretation of Antidepressant Meta-analysis

Researchers question the overstated results of a large antidepressant meta-analysis and point to cultural pressures to turn to these drugs for a quick fix.

Study Links Antidepressants and Decreased Coping Behaviors Across Generations

Biologists found that exposure to antidepressants suppresses important survival behaviors in zebrafish, an effect that persisted across three generations and was found to be more severe for males.

Researchers Push Back Against Recommendation to Combine Antidepressants for Suicide Prevention

Researchers challenge the recommendation of starting two antidepressants simultaneously to increase preventative effects against suicide.

Researchers Ask, ‘Why Do Antidepressants Stop Working?’

An international group of researchers, including several with financial ties to manufacturers of antidepressants, explore possible explanations for why long-term users of antidepressants become chronically depressed.

Increased Suicidality in Cymbalta Trial for Fibromyalgia in Teens

A new as-yet-unpublished trial of duloxetine (Cymbalta) for fibromyalgia has presented more evidence of suicidal events in teens.

Reanalysis of STAR*D Study Suggests Overestimation of Antidepressant Efficacy

Reanalysis of the original primary outcome measure in the STAR*D study suggests STAR*D findings inflate improvement on antidepressant medication and exclusion criteria in conventional clinical trials results in overestimation of antidepressant efficacy.

Researcher Challenges Clinical Effectiveness of Antidepressants

A new article in BMJ Evidence-Based Medicine addresses common misinterpretations of the efficacy research on antidepressants.

SSRI Exposure in Pregnancy Alters Fetal Neurodevelopment

Alterations in gray matter and white matter development found in infants of mothers taking SSRI antidepressants during pregnancy.

Suicide in the Age of Prozac

During the past twenty years, the American Foundation for Suicide Prevention and American psychiatry have adopted a "medicalized" approach to preventing suicide, claiming that antidepressants are protective against suicide. Yet, the suicide rate in the United States has increased 30% since 2000, a time of rising usage of antidepressants. A review of studies of the effects of mental health treatment and antidepressants on suicide reveals why this medicalized approach has not only failed, but pushed suicide rates higher.

Citizens Petition Calls for Sexual Side Effect Warnings

Researchers take action after study exposes enduring sexual dysfunction as a potential side effect of serotonin reuptake inhibiting antidepressants, 5α-reductase inhibitors, and isotretinoin.

Antidepressants Are Not More Effective for Severe Depression, Study Finds

A new study, published in Acta Psychiatrica Scandinavica, found that antidepressant efficacy was not dependent on severity.

Review of Pediatric Antidepressant Studies Finds Evidence of Benefit Lacking

Review of pediatric antidepressant studies finds the vast majority are negative on primary outcomes and an increased risk for suicidality.

Review Finds Lack of Evidence for Antidepressants in Treatment of Insomnia

Results from a Cochrane meta-analysis find that the common practice of prescribing antidepressants to treat insomnia is not supported by current evidence.

Increasing Antidepressant Dose Does Not Improve Outcomes

A systematic review of literature and meta-analysis indicates that there is no clinically or statistically significant effect of antidepressant dose increase after nonresponse to initial treatment.

Antidepressant Use Leads to Worse Long Term Outcomes, Study Finds

Results from a 30-year prospective study demonstrated worse outcomes for people who took antidepressants, even after controlling for gender, education level, marriage, baseline severity, other affective disorders, suicidality, and family history of depression.

New Study Concludes that Antidepressants are “Largely Ineffective and Potentially Harmful”

A new study published in Frontiers in Psychiatry concludes that “antidepressants are largely ineffective and potentially harmful.”

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