Withdrawal Symptoms Common for Those who Stop Taking Antidepressants

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A new study, published in Molecular Psychiatry, investigates the prevalence and typical characteristics of antidepressant withdrawal syndrome (AWS) through analyzing available research. Researchers found...

Antidepressants Cause Cardiovascular Disease, Study Finds

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A new study published in BMJ Mental Health finds that antidepressants are associated with cardiovascular disease (CVD). The authors employed Mendelian randomization, a method...

Study Finds No Increased Risks for Pregnant Women Who Discontinue SSRIs/SNRIs

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A new article published in Pharmacy and Clinical Pharmacology finds pregnant women that chose to stop using selective serotonin reuptake inhibitors (SSRIs) and serotonin...

Study Finds Over 25% of Antidepressant Prescriptions Given to High-Risk, Long-Term Users

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A new article published in BMC Medicine finds that antidepressant use in two Scottish regions increased 27% between 2012 and 2019. The current work,...

Antidepressants Linked to Lasting Sexual Dysfunction, Study Finds

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New research highlights the challenges in quantifying the prevalence of Post-SSRI Sexual Dysfunction (PSSD), a condition that continues to affect patients long after they stop taking antidepressants.

Antidepressant Withdrawal: A Psychiatrist’s 30-Year Challenge to Conventional Wisdom

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For thirty years, Dr. Giovanni Fava has sounded the alarm on the long-term effects of antidepressants and the risks of withdrawal, pushing back against pharmaceutical narratives.

Antidepressant Withdrawal Commonly Misdiagnosed as “Mental Illness”

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A new study reveals that more than two-thirds of patients experiencing antidepressant withdrawal were misdiagnosed with psychiatric disorders.

Antidepressants Overprescribed to Post-Menopausal Women Despite Risks

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A new study reveals that antidepressants, commonly prescribed to post-menopausal women, may increase risks of falls, cognitive decline, and cardiovascular issues, raising questions about their overuse in this population.

Antidepressant Trials “Hijacked for Marketing Purposes,” Researchers Say

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About half of the large antidepressant trials are biased enough to be considered “seeding trials,” according to the researchers.

Antidepressant Use in Pregnancy Harms Child Development, Untreated Maternal Depression Shows Benefit

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In this new study, exposure to maternal anxiety in utero also harmed child development.

Common Side Effects Leading to Antidepressant Discontinuation

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New research finds the negative drug effects most commonly associated with initiating antidepressant discontinuation are anxiety, suicidal thoughts, vomiting, and rashes.

Antidepressant Use Linked to Sexual Dysfunction, Why Aren’t Prescribers Discussing It?

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Research sheds light on the impact of antidepressants on sexual dysfunction, emphasizing the need for patient-physician communication.

Antidepressant Use Tightly Correlates with Increased Suicide Rates

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While the study can’t confirm causality, it does contradict the notion that antidepressants reduce suicide at the population level.
3D illustration of a matrix with tablets and the words risks and benefits. Concept of clinical trials results

Two Out of Three Find Antidepressant Effects Not Worth Burdens

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New study reveals: 2 in 3 people need more than the current antidepressant benefits to consider them worthwhile.

Antidepressant Exposure In Utero May Negatively Impact Motor Skills in 2-Year-Old Children

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A new study in Frontiers of Pharmacology finds that antidepressant use during pregnancy is linked to reduced motor skills in children at 2 years...
3D render of placebo pills isolated over wood background

Placebo Effect—Not Antidepressants—Responsible for Depression Improvement

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In adolescent depression treatment, those who received a placebo but thought they received Prozac improved more than those who received the drug and knew it.

Stop Using Antidepressants Except for “the Most Severe Depression,” Experts Say

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Experts advocate limiting antidepressant use to only the most severe cases of depression, emphasizing the need for social and psychological interventions.
Pregnant woman visiting young psychologist

Animal Study Shows Impact of Prozac in Pregnancy on the Child

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Researchers found that rats born to mothers given the antidepressant Prozac during pregnancy or breastfeeding exhibited varied behavioral and developmental effects, with implications for the understanding of antidepressant impacts during human pregnancies.

SSRI Use During Pregnancy Alters the Child’s Brain Development

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Reduced brain volumes due to SSRI exposure in pregnancy was not explained by maternal depression alone.
Pile of pills in blister packs background

Psychiatric Journals’ Pro-Pharma Publication Bias Hides Suicide Risk of Antidepressants

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Selective publication bias in top psychiatry journals was not explained by the quality of the studies, but by financial ties to pharma.
Top View of Girl Sits on Bed with Scattered Pills. Little Child Sitting on Gray Badcover Near Opened Packing of Medicines Keeps Head with Hands. Unhappy Childhood Concept

Antidepressants Increase Suicide Attempts in Youth; No Preventative Effect

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Researchers find that SSRIs increase suicide attempts up to age 24, and have no preventative effect at any age, even for those at high risk of suicide.

No Benefit for Adding Antidepressants to CBT in Severe Depression

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For those with severe depression, inpatient CBT was effective but the adding antidepressants did not improve treatment outcomes.

New Data Reveal the Full Extent of STAR*D Failure

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The initial study, which has been used to promote antidepressants, employed outcome switching to hide poor results.

Lexapro for Children: Drug With No Meaningful Benefit and Increased Suicidality Gets FDA Approval

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Response and remission rates were the same in the drug versus placebo groups, and Lexapro increased suicidality sixfold.
Battle of the brains and war of wit concept as two opposing open human brain symbols fighting as a debate or dispute metaphor and an icon for creative competition in a 3D illustration style.

Pharma CEO, Others Attempt Contradictory Critiques of Serotonin-Debunking Study

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Moncrieff et al. respond to the contradictory and, in some cases, false concerns raised by these critics of their serotonin review.