New Guidance on Antidepressant Withdrawal for Doctors in the UK
New guidance for primary care doctors in the UK on antidepressant discontinuation acknowledges severe and long-lasting withdrawal symptoms.
Understanding the Neurobiology of Post-SSRI Sexual Dysfunction
Post-SSRI sexual dysfunction (PSSD) may be a common adverse effect of antidepressants. Researchers are now attempting to understand the neurobiology behind it.
Researchers Seek Standardized and Safe Antidepressant Tapering Protocol
A new study promotes the use of a standardized approach to antidepressant tapering.
Therapy Beats Drugs for Depression for Long-Term Outcomes
Combining drugs and therapy also did not lead to better depression outcomes than therapy alone.
Antidepressants Plus Immune Response Terminate Pregnancies in Mice
Also, male mice born to mothers with an immune response exhibited “autistic-like” behaviors, scientists report.
Animals Exposed to Antidepressants in Utero Are Worse at Taking Care of Their Own...
A new study in rats found that those exposed to antidepressants in utero had an impaired ability to nurture their own children in later life.
Gradual Tapering Recommended for Antidepressant Discontinuation
A new literature review reinforces the need to “down-titrate” or taper antidepressants, especially drugs like Celexa and Paxil.
Antidepressant Withdrawal Linked to Suicide Attempt in Case Study
Researchers suggest that antidepressant withdrawal can be a possible precipitant of suicide.
Long Term Antidepressant Use Associated With Increased Morbidity and Mortality
A study finds that commonly prescribed antidepressants are associated with the development of diabetes, hypertension, and other diseases.
Health Risks to Babies When Antidepressants Used During Pregnancy
Babies born to mothers taking antidepressants during pregnancy were more than six times as likely to have neonatal withdrawal syndrome—including breathing problems, irritability/agitation, tremors, feeding problems, and seizures—than those born to mothers taking other types of drugs.
Antidepressants No Better Than Placebo for About 85% of People
Researchers can’t predict the 15% who benefit from antidepressants, and the other 85% are unnecessarily exposed to the harms of the drugs.
Less Than a Quarter of Those with Depression Respond to Treatment in Real Life
In a real-world setting, less than a quarter of patients diagnosed with depression improved with medication, hospitalization, and therapy.
Antidepressant-Induced Serotonin Syndrome a Danger for the Elderly
Researchers found that 25% of elderly patients taking antidepressants had serotonin syndrome, which is potentially life-threatening.
How to Distinguish Antidepressant Withdrawal from Relapse
Mark Horowitz and David Taylor provide advice on how to tell the difference between antidepressant withdrawal and depression relapse.
Did Psychiatry Ever Endorse the Chemical Imbalance Theory of Depression?
With the chemical imbalance theory falling out of fashion, researchers examine the claim that psychiatry never truly endorsed it.
Antidepressants Do Not Improve Quality of Life
A new study found that taking antidepressants did not improve quality of life.
Patient Reports Reveal SSRI Antidepressants Often Lead to Emotional Blunting
According to patient reports, SSRI antidepressants most frequently lead to the subjective experience of emotional blunting.
Official Guidelines on Antidepressant Discontinuation Fail Practitioners and Patients
A review of clinical practice guidelines for antidepressant discontinuation from across the English-speaking world reveals major pitfalls.
Shifting Away from ECT and Antidepressants for Depression
Researchers argue that we need a paradigm shift away from the biomedical model of mental illness to one informed by political action and common sense.
Negative Antidepressant Trials Still Unlikely to Be Published
Antidepressant trials with negative results are still more likely than not to either be misleadingly spun as positive or unpublished.
SSRI Antidepressants Do Not Improve Depression After a Stroke
A study in JAMA Neurology finds that antidepressants do not reduce depression symptoms more than placebo in patients recovering from a stroke.
New Review: Antidepressants Come with Minimal Benefits, Several Risks
A review of research on antidepressant efficacy finds that an unfavorable risk-to-benefit ratio.
Overuse of Psychiatric Drugs is Worsening Public Mental Health, Doctor Argues
A new research article asserts that the overuse of psychiatric drugs may create neurobiological changes that hamper long-term mental health recovery.
Researchers Push to End Placebo Run-in Periods in Antidepressant Studies
Meta-analysis finds that the placebo run-in methodology reduces the placebo effect and finds antidepressants to be less useful.
Withdrawal Symptoms Cloud Findings of Antidepressant “Relapse” Trial
Leading researchers point out that a new antidepressant study in NEJM failed to account for withdrawal symptoms, casting doubt on the results.