The Taint of Eugenics In NIMH-Funded Research Today

Robert Whitaker

Recently, Thomas Insel, director of the National Institute of Mental Health, identified the “NIMH’s Top 10 Research Advances of 2011.” He wrote:

“This has been a year of exciting discoveries and scientific progress . . . Here are 10 breakthroughs and events of 2011 that are changing the landscape of mental health research.”

His words fit neatly into a larger narrative in psychiatry, which is that of science on the march. For the past 30 years (or even longer), leaders in the field have regularly told of “great advances,” and of how “extraordinary” new research is leading to “tremendous advances” in care, and Insel’s list is the latest addition to that narrative. And yet—and this is the puzzling part of this modern tale of scientific progress—the burden of mental illness in our society keeps going up and up, and clinical outcomes have, in anything, worsened in the past 30 years (at least for affective disorders.)

So, in the hope of gaining some insight into this mystery, let’s take a closer look at Insel’s list of “exciting discoveries” and “breakthroughs” from the past year. Here are the titles for the top five:

Complexity: Discovering New Sources of Genetic Variance.
Transcriptome: Developing Brains Have Unique Molecular Signatures.
Induced Pluripotent Stem Cells: Disease in a Dish.
De Novo Genetic Variants.
Epigenomics: How Experience Alters Behavior.

If your initial response is like mine, you may be tempted to say: what a bunch of molecular gobbledygook. But then I took a deep breath and sought to identify, in a more clear-headed way, why this list is so disappointing.

The first reason is a practical one. Researchers have spent the last 30 years trying to identify molecular and genetic explanations for psychiatric disorders, but this effort has not led to any therapeutic advance. In fact, it is proving so barren that many drug companies are shutting down their efforts to develop new psychiatric drugs, precisely because such research has failed to identify promising new molecular targets. So why keep on pursuing this tack? Might it be time to put our federal dollars into research more likely to produce a therapeutic benefit?

But the second reason for disappointment is the more important one. Insel’s list tells of a research enterprise devoted to identifying what is genetically wrong with the “mentally ill.” As the history of eugenics reminds us, that is a pursuit, unless it is handled with great care, that can engender bad social policy and a great deal of harm.

In 1869, Sir Francis Galton, cousin to Charles Darwin, gave birth to eugenics when he published a book titled Hereditary Genius. In it, he concluded that it was nature, rather than nurture, that made the superior man. Thus, he argued, humans were decidedly unequal. Democratic ideals that men were of “equal value,” he wrote, were simply “undeniably wrong and cannot last.”

This was a sentiment that rang true to one group in American society: the ruling elite with a White Anglo Saxon Protestant heritage. Many believed that a large influx of non-WASP immigrants was weakening the country. Soon, American eugenicists were busily ranking ethnic groups along a “more fit and less fit” spectrum, and the “insane” were put at the bottom of the list. Eugenicists then argued that in order to keep America strong, it was necessary to encourage those with “good germ plasm” to have lots of children, and to prevent those with “bad germ plasm” from breeding.

In 1896, Connecticut became the first state to prohibit the “insane” from marrying. Other states followed suit, and by 1933, there were no states left where the insane could legally tie the knot. However, the problem with such laws, eugenicists lamented, was that few people seeking a marriage license declared themselves insane. The insane, one eugenicist noted, are “biased” in their own favor.

Thus, since that social policy didn’t do the trick, eugenicists began arguing that the insane needed to be segregated from society in mental hospitals. They needed to be locked up and kept there until their breeding years passed. This belief—that the “insane” needed to be removed from society—led to a rapid buildup in the number of hospitalized mentally ill, which increased from 31,973 in 1880 to 272,527 in 1929.

At that time, a Journal of Hereditary editorial concluded that “segregation of the insane is fairly complete.” But eugenicists had also been advocating for a more permanent solution to the “breeding” problem, and now they got their wish. In 1907, Indiana had become  the first state to authorize forced sterilization of people with “hereditary defects,” and in 1927, the U.S. Supreme Court declared such state laws constitutional. By the end of 1945, more than 45,127 Americans had been sterilized under such laws, 21,311 of whom were patients in state mental hospitals.

As such social policies took hold, a number of scientists at top colleges promoted eugenics as a science. By 1914, 44 colleges in America had introduced eugenics into their curriculums, and such courses were particularly popular at such elite schools as Harvard, Columbia, Cornell and Brown. By 1924, more than 9,000 research papers on eugenics had been published, and the Eugenics Research Association could boast that a third of its 383 members were fellows of the American Association for the Advancement of Science, the national’s most prestigious scientific group.

The physician who took the lead in proving that insanity was an inherited disease was Aaron Rosanoff, a physician at Kings Park State. He charted the family histories of 72 insane patients, but initially he did not find the results he expected. Among the 1,097 relatives of the 72 patients, only 43 had ever been hospitalized for a mental illness, a number far too low to show a causal genetic link. But Rosanoff was determined to prove there was one, and so he decided that he had defined mental illness too narrowly. If he expanded the definition of what could be considered abnormal behavior, and thus could include people who were “high strung, excitable, dictatorial, or abnormally selfish” as mentally ill, he determined that the 72 patients had 351 relatives who were mentally unwell. This was very close to the precise number he needed to conclude that insanity was a single gene recessive disorder, transmitted much like blue eyes. If a child inherited a copy of the normalcy gene from one parent and the insanity gene from another, he or she would grow up to be normal but would be a “carrier” of insanity. A child who got the insanity gene from both parents was doomed to be insane as an adult, he wrote.

This “finding,” and other such findings said to prove that mental illness was a genetic illness, naturally led the public to fear the hospitalized mentally ill. Their genes were a threat to society’s collective gene pool. Meanwhile, in their writings, eugenicists described the mentally ill  as “social wastage” and as “unfit” human beings, and talked about the need to remove this “social cancer” from American society. With such declarations influencing the American mind, 66% of the public said in 1937 that they favored sterilizing the “defectives” in society.

This disparagement of the mentally ill naturally led to a drop in public funding for state mental hospitals, and many fell into total disrepair. In addition, it set the stage for psychiatry, in the 1930s and 1940s, to embrace a quartet of medical therapies that were understood to “work” by damaging the brain. The therapeutic reasoning was easy to understand: If the mentally ill had little value, and were generally “unfit” human beings, then therapies that quieted them and made them easier to manage—even if they seemed to knock the patients down to a lower level of being—could be embraced as helpful. The first three such therapies were insulin coma therapy, metrazole convulsive therapy, and repetitious electroshock therapy. The fourth was frontal lobotomy, which at the time was hailed as a miracle brain surgery.

Today, as a society, we would never conclude that we hold “eugenic” ideas about the “mentally ill.” Eugenics became a discredited science at the end of World War II, when it became evident that Hitler had risen to power on a eugenics agenda, and that this grading of humans—into the fit and unfit—had led to the Holocaust. Yet, it is easy to see today that our modern research agenda has encouraged eugenic conceptions of the mentally ill and encouraged the adoption of policies that rob people so diagnosed of their basic rights.

In 1980, when American psychiatry published its third edition of its Diagnostic and Statistical Manual, it informed the public that mental disorders were now to be thought of as “diseases of the brain,” much like diabetes or some other physical illness. The mentally ill were said to have “broken brains,” characterized by faulty “brain chemistry.” Trauma, environmental stressors, difficult family relationships, and other problems were no longer to be seen as primary causes of psychiatric distress. The root cause was an internal biological flaw with the person. With this conception in mind, NIMH-funded researchers renewed a quest, first born in the eugenics era, to identify a genetic basis for psychiatric disorders.

There is, of course, an understandable therapeutic rationale for such research. If a biological pathology, arising from a genetic defect, can be identified, then it would provide a target for drug development. But—and this is important to recognize—this research has not proceeded in an ideologically neutral manner. In 1980, with the publication of DSM-III, the field became ideologically committed to telling a certain story, which is that mental disorders are brain diseases. As such, the field became committed to proving that this was so, and we can see this ideological impulse in many of the published findings. You find it in particular in the MRI studies, in which researchers may announce that some abnormality or another has been found in a group of patients, without making an effort to distinguish whether the abnormality is medication induced. When that happens, ideology is trumping honest inquiry and science, and it is impossible, as such moments, to not be reminded of Aaron Rosanoff, and his desire to report that insanity was a single gene recessive disorder.

In terms of shaping public opinion about mental illness, what has this modern genetics research wrought?  When we hear of how people diagnosed with schizophrenia or bipolar disorder have “broken brains,” or that these disorders have a genetic basis and run in families, we are being encouraged, as a society, to think of people so diagnosed as not quite “right,” or that they are “unfit.” As such, we shouldn’t be surprised that recent studies have found that as the public comes to understand that mental disorders are “biological” in kind, stigma toward the “mentally ill” increases.

In short, thirty years of NIMH-funded research into the possible genetic causes of mental disorders has proven to be both a therapeutically barren enterprise and one that has encouraged eugenic conceptions of the mentally ill. Those eugenic conceptions are now showing up in our social polices, and this can be clearly seen in our society’s embrace of “outpatient commitment” orders. The public has been encouraged to “fear” the mentally ill, and to conceive of them as driven in their behaviors by their faulty brain chemistry and genes, which they can’t control, and thus society embraces the idea that “they”—i.e. the other in our midst—need to be kept under state control.

A century ago, such societal beliefs led to the segregation of the mentally ill in hospitals. Today, people may get released from hospitals, but if they are under an outpatient commitment order, they certainly are not “free” and enjoying the rights of full citizenship. They may be forced to take medications that they do not want to take, and if they complain that the drugs make them feel like “zombies” and rob them of their capacity to feel the world, such complaints are dismissed. They don’t know what is good for them, we say.

This state control of the “mentally ill” extends beyond those under an outpatient order to many who receive government services. Such people may not be under a legal order, but still feel coerced. They may have to take medications they don’t like in order to continue to receive services, and such coercion surely is an impingement on their self-autonomy.

This, of course, is true regardless of the merits of the medications. If a person living in society is being forced to take a medication he or she does not want to take,  that is impinging on his or her usual rights as a citizen. Their right to liberty has been compromised.

Now, let’s return to Insel’s list for a second look. Only this time, instead of focusing on what is named on the list, let’s look at what is missing. See if you can find even one item that tells of research designed to help living, breathing human beings get well and stay well. See if you can find anything  that tells of research designed to identify the strengths that can be found in people struggling with their minds, and all the ways that, in fact, such struggles can be an ordinary part of human experience.

Once again, history can tell us why it is tragic that such research is missing from the NIMH list.

In the last years of the 18th century, Quakers in York, England, acting in rebellion against the harsh ministrations of English mad doctors, developed a form of care known as “moral therapy.” The medical wisdom at the time was that the mad, by virtue of having lost their reason, had descended to the level of “brutes, but the Quakers in York thought differently: They declared that the “mad” were “brethren” and should be treated as such.  The Quakers in York built a small retreat in the countryside, where the mad were given shelter and food, and treated with gentleness and kindness. In this manner, the Quakers hoped to “assist nature” in helping the mad get well. They believed that their mad brethren had a God-given inner capacity for regaining self-control and reason, and thus their therapeutic challenge was to provide a gentle environment that could best promote such healing.

In fairly short order, the Quakers in York reported that this care was proving to be quite successful, and in the first decades of the 19th century, Quakers in the United States built a number of such small retreats, in the countryside outside Boston, Philadelphia, Hartford and other cities. The patients were encouraged to garden, exercise, take long walks, and engage in social activities. And this therapy worked. Modern historians who have reviewed the records of these retreats have determined that more than half of the newly insane would be discharged within three years.  Moreover, a long-term study of 984 patients discharged from Worcester Asylum in this period found that 58% remained well throughout their lives.

Today, we often hear of how our society is discovering that some people can “recover” from mental illness, as if this is an extraordinary finding. If the Quakers from the early 19th century could hear such pronouncements, they would undoubtedly furrow their brows and wonder, this is considered new?

Imagine if the NIMH revisited this history and funded studies mindful of the lessons to be gleaned from it. NIMH-funded investigators, rather than seeing people with a psychiatric diagnosis as having an innate defect, would see them instead as “brethren,” and thus as human beings having an inner resilience and an inner capacity for getting better.  The investigators could then focus their efforts on developing therapeutic approaches that help nurture such inner strengths. The Quakers found that diet, exercise, meaningful work and social engagement were a recipe that could help many disturbed people get better, and I imagine that if the NIMH invested in this idea today, researchers would discover anew their benefits.

Yet—and I know this well—that is a wish-list thought. The NIMH has published a list of its “Top Ten Research Advances of 2011,” and pronounced them to be “exciting discoveries” and “breakthroughs,” and so undoubtedly we will see much more of this type of research, which unfortunately encourages us, as a society, to think of people who may struggle with their minds not as “brethren,” but as fundamentally “unfit.”  Even well-meaning research can have unintended consequences, and I think, if we look at our ongoing genetics research within a historical light, we can see why that is so.

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  1. Yes, yes! Well said! The NIMH should be funding research on what successfully fosters recovery, wholeness and healing, because recovery does happen! Great idea.

    As for genetic research, the NIMH could study monozygotic twins, where one has a diagnosis of a severe mental “illness” and the other is “normal.” Much could be learned from how the “normal” twin fared so well despite his/her “problematic” genetic material. They could start with the Spiro twins, Pam and Carolyn, featured in the book, Divided Minds. Pam got diagnosed with schizophrenia, while Carolyn became a psychiatrist. Hmmm . . .

  2. Amazing that I just commented about the biological psychiatry advocated doctor here and mentioned eugenics as part of this bogus profession’s history. Dr. Peter Breggin exposed that the NAZI DOCTORS (book by Dr. Jay Lifton)brought their evil eugenics theories/beliefs to American and started their WAR AGAINST CHILDREN OF COLOR. Thre is a book that describes how the definition of schizophrenia was changed to apply to so called angry black men!!

    It is a well known fact that “Dr.” Insel is one a of a tight group of paid shills for big PHARMA as evident when Senator Grassley exposed the paid shills Nemeroff and Beidermman as well as other drug company front people and groups like NAMI.

    I have shuddered to read about Insel’s new goal of finding the mentally ill genes in psychiatry’s many victims who are most frequently normal people having life problems falsely accused of being bipolar and other latest fraud fad stigmas.

    Biolgical psyciatry should be abolished and taxpayers should revolt againt this monstrous medicalization of normal human behavior. They have invaded every area of our lives with their many crimes against humanity and it’s time they got their own Nuremburg Trials to end their neverending witch hunts and inquisitions.

    Thank you Robert Whitaker for this excellent eye opening article like your great books and further warning to avoid the mental death profession like the plague it is and always will be since it is obviously made up of sociopaths and malignant narcissists.

  3. ADDENDUM: I realize many deemed mentally ill appear so due to an emotional, physical, spiritual, stress breakdown. Dr. Loren Mosher with his Soteria project like the Quakers proved that being treated with respect, compassion and like human beings caused such people to recover without drugs and other toxic treatments. On the other hand, facing lying, abusive ,psychopathic reductionist crazymaking psychiatrists is enough to drive anyone over the edge. They are more violent and cruel than their patients for sure.

    It is very hard to type comments here so please forgiven the typos.

      • I don’t think there is anything clueless about this. This plague on humanity by biolgical psychiatry is DELIBERATE in that they are psychopaths who with their cohorts in crime in the power elite plutocracy with to destroy any dissidents who see throught their attempt to dominate the world like the Hitlers and Stalins of fascist countries of the past. They made no secret of the fact that the biggest lies through great propaganda are least likely to be challenged or disbelieved. This is what we are facing in all so called first world countries: an endless assault on humanity and normal people by psychopaths and those most susceptible to them so they can fulfill their agenda of one world order with the psychopaths or most evil people in control so they can exploit and destroy real humans with impunity as the intraspecies predators they are.

        They do not believe this garbage of biolgoical psychiatry themselves, but rather see it as an effective con, fraud of which psychopaths are the chief experts and pathological liars and manipulators to fullfill their evil mission to keep the word at war and in the majority in constant misery, slavery and poverty while they continue to stal all the wealth. Notice these fiends as in Stalinist Russia are targeting children, especially the best and the brightest to brainwash and destroy so they won’t pose much challenge or threat once brain damaged and deprived of their very humanity, intellignece and creativity with bogus stigmas and lethal drugs. The fact that normal humans have allowed this monstrosity to occur with little complaint for the most part shows that we have lost our moral compass, whcih invites the Hitlers of the world to come to power as a necessary wake up call to humanity. Dr. Fred Baughman does a great job exposing this assault on children in his book ADHD FRAUD and many web articles. So does Dr. Peter Breggin in his RECLAIMING OUR CHILDREN, THE WAR AGAINST CHILDREN, TALKING BACK TO RITALIN, etc. See related book, POLITICAL PONEROLOGY, by a survivor of this horror and expert in psychopathy who does an excellent job of explaining this horrific process from training and agonizing experience.

        Let’s not pretend that these fiends in bed with BIG PHARMA are doing anything scientific for the benefit of real humans. It is all about greed, power, profit, status and using normal humans as fodder for the benefit of these psychopaths only. They have committed massive fraud with pathological lying deliberately to gain sadistic power over humanity in keeping with their own character disorders, so giving such psychopaths the benefit of the doubt repeatedly is always a very dangerous idea per Dr. Robert Hare, world’s foremost authority on psychopaths who invented the renowned psychopath test used world wide, the PCL-R. His books, WITHOUT CONSICENCE: THE DISTURBING WORLD OF THE PSYCHOPATHS AMONG US and SNAKES IN SUITES: WHEN PSYCHPATHS GO TO WORK explain this real threat to the public and humanity in general as have many before him like Dr. Harvey Cleckley with his classic work, THE MASK OF SANITY and Robert Lindner’s REBEL WITHOUT A CAUSE. there has been an explosion of web and other articles and books on psychopathy/sociopathy/malignant narcissists in recent times now that psychiatry has helped to destroy all our social institutions and even robbed us of the right to name evil by medicalizing that too by providing the insanity defense for their fellow criminals who can’t con their way out of their many crimes . As Dr. Szasz says, “Whenever psychiatry enters the courts, those who should be in prison stay out and those who should not be in prioson are imprisoned!!” Needless to say, the mental death porfession does not include Dr. Hare’s terms or results in their bogus junk science DSM since it hits too close to home.

  4. The problem is always one of point of view and hope for a “one size fits all” solution. Clearly not all are helped by pastoral settings and many are abused by forced medication, but the universe made up by those who carry a diagnosis of some mental disorder is anything but uniform. Advocating for research that focuses on what is helpful is woefully underrepresented but knowledge of brain function may ultimately be beneficial to a smaller segment of those with illness, but not all.

    If the article can be seen as expressing legitimate criticism of the lack of balance and a warning of abuses that need to be addressed as opposed to an overall indictment of psychiatry as a whole, it will help with sorely needed changes.

    My experience is that the more extreme the criticism, the more resistant to change by those supporting the “opposing” view. I hope for everyone’s sake Mr.Whitaker’s comments are heeded and a sense of balance can be reached. The left-brained scientists would do well to pause and consider the right-brained humanistic points presented here. It is not simply a matter of experimental science.

    • Fraud is fraud and science and medicine should be based on ethical, honest trials, studies and other methods with the reports similarly honest and transparent. Allowing an evil group of psychopaths to keep burning witches at the stake just because annoying them with the facts would make them more entrenched just keeps their evil going much longer. As with the tobacco companies, BIG PHARMA has kept their murderous products going with the science of doubt or rather lack of science.

      I just watched an excellent DVD called THE BILLIONAIR’S TEA PARTY available in public libraries that shows how the so called grass roots tea party movements were anything but that. They were instigated by many billionaires deceiving local groups of people to protest against their own best interests as with the Koch brothers denying global warming for years to make more billions at the cost of our planet’s survival. BIG PHARMA, BIG TOBACCO and others multibillion dollar murder enterprises paid millions for front groups and propaganda to further their interests while conning people to protest on their behalf and against their own best interests. This is why factual, truthful information is critical while being very careful to check out any supposed scientific, health or other claims. CAVEAT EMPTOR about the contents of your own mind.

      As one expert said, thanks to the billionaires and their corporations that now have their own personal and civil rights to furthers exploit and harm us, we are DROWNING in propaganda. Some of the people “protesting” were obvious driven to hysteria and what might be called temporary insanity as with the witch hunts/trials!! See book and film, THE CORPORATION, whereby the author with Dr. Robert Hare’s assessment could be seen as psychopathic or plain evil!

      • ADDENDUM

        Correction: In the above, I meant at the end that THE CORPORATION could be seen as psychopathic and not the author or Dr. Hare. You can read reviews at AMAZON and elsehwere.

        Forgive other typos, it is rather difficult to type, navigate and correct typos on this site.

  5. Bob Whitaker’s latest article demonstrates once again modern psychiatry’s resemblance to the drunk who lost his keys on a dark street, and then looked for them only near lampposts, since that was where the light (the funding?) was. Psychiatry’s decades-long focus on brain disorder has also implied irreversibility – so at best it has functioned with one hand tied behind its back.

    Psychosocial experiences represent both cause and cure of most mental illness – a fact which psychiatry, my specialty since 1946, has systematically ignored. Persecutory experiences have always been a significant cause of mental illness, whether or not the victims came to official attention. While the Freudians paid attention to painful childhood experiences (while ignoring the far more important adult ones), the psychopharmacologists who took over American psychiatry in the 1960’s have ignored experiences and focused instead on biology and chemistry.

    In my own case, described earlier, although I knew the harassment to which I was being subjected – I had kept careful written records! – which I sometimes exaggerated and to which I sometimes responded inappropriately, the psychiatrists caring for me consciously and deliberately refused to examine these, the real causes of my breakdown. My recovery, like those of the many chronic schizophrenic state hospital clinic patients whom I then treated, was the result of my focusing on their engaging in “useful and satisfying” activities, which restored their self-esteem and capacity to function. Treatment’s prime goal should be restoration of social functioning, with recovery of painful experiences being sought only insofar as needed to attain that primary goal.

    But when psychiatry refuses to face the specific social factors causing breakdowns, as it did with me, it becomes an accomplice in their creation.

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  7. Thanks once again, Bob, for shining the light on the long-term and on-going connections between eugenics and psychiatry.

    I wish Insel and his gang would stop conflating “brain” and “mind.” Seems to me that anyone who’s taken an intro to philosophy course would get that these are two different things.

  8. Thank you, Bob. I’m just amazed that an entire industry, who should theoretically be fully aware of the evils and fraud of the Nazi eugenisists, is still wasting billions in taxpayer money researching the eugenics of so called “mental illnesses.” Perhaps it says something rather evil about those financing the research as well?