The authors of an article in Journal of Psychosocial Nursing reviewed the literature on psychotropic PRN medications in order to respond to a request to clarify the best protocol for nurses at St. Vincent’s hospital in Sydney, Australia. They found “considerable variation in nursing practices related to administration of PRN medication. In an area of practice that is undertaken with such regularity and with considerable potential impact on consumers, these findings point to the need for further research to establish best practices.”