A comprehensive meta-analysis of randomized trial data by researchers from the Harvard School of Public Health finds that children and young adults who start antidepressants at high doses appear to be at greater risk for suicidal behavior.
Miller, M., Swanson, S., Azrael, D., Pate, V., Stürmer, T.; Antidepressant Dose, Age, and the Risk of Deliberate Self-harm. JAMA Internal Medicine. Online April 28, 2014. doi:10.1001/jamainternmed.2014.1053
High Doses of Antidepressants Appear to Increase Risk of Self-Harm in Children, Young Adults (JAMA Psychiatry)
High Dose of Antidepressants Increases Risk for Suicidal Behaviour in Children and Young Adults (Science World Report)