University of California researchers have determined that some naturally occurring human-resident bacteria can and do produce substances which have drug-like properties — though more research is required before they can determine the exact properties and effects of those drugs.
“Bacteria that normally live in and upon us have genetic blueprints that enable them to make thousands of molecules that act like drugs, and some of these molecules might serve as the basis for new human therapeutics,” stated a press release from the University of California at San Francisco. The team’s research was published in the journal Cell.
In their preliminary study, the team found that, “remarkably,” the capacity to produce drug-like antibiotics in particular was widespread among human microbiota. They even isolated one “previously unknown antibiotic” being produced from a common vaginal bacterium. “Our findings illustrate the widespread distribution of small-molecule-encoding BGCs in the human microbiome, and they demonstrate the bacterial production of drug-like molecules in humans,” they concluded.
“We used to think that drugs were developed by drug companies, approved by the FDA, and prescribed by physicians, but we now think there are many drugs of equal potency and specificity being produced by the human microbiota,” said Michael Fischbach of the UCSF School of Pharmacy in the press release.
The findings add to research previously reported on MIA of the influence of common gut microbiota on moods.
Our Microbes Are a Rich Source of Drugs, UCSF Researchers Discover (University of California – San Franciso Press Release on Newswise, September 5, 2014)
A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics (Donia, Mohamed S et al. Cell. September 11, 2014. Volume 158, Issue 6, p1402–1414. DOI: http://dx.doi.org/10.1016/j.cell.2014.08.032)
See also from Mad In America:
Gut Bacteria Can Influence Health and Moods
More Evidence Linking Diet, Gut Microbes, Moods
ha! I have a post going up at midnight about this.
I find it amusing that they’re calling our own microbiome drugs…I find it a bit ludicrous really.
Healthy bacteria are just part of how we’re made…we have gotten unhealthy because our diets and environments and the pharma we put in our bodies have wiped out our healthy bacteria…
bacteria are “drugs” just as good food is medicine…
we should be ingesting all this stuff regularly as part of our diet…to call them drugs is just kind of ass-backward…
except again, in the sense, that food is medicine…
so, here’s the post if anyone wants additional information and comments on this topic:
Gut bacteria play a role in mood and emotion
Good Morning Monica
“drugs” sounds to me like the medicalization slippery slope.
I completely agree – we would be more correct to say that “drugs mimic the effects of naturally-occurring bacteria” than that “bacteria produce drugs.” And the conclusion should not be that we can use bacteria to create new drugs or as a biological drug factory, but that we should be looking to naturally-occurring bacterial symbiosis as a possible solution to many health problems we experience.
But some people have no respect for life or nature…
Great points. Gut microbiota are our symbionts and we can’t be healthy without them. Feeding them junk food is bad for them and bad for us.