A study published in this month’s issue of the Journal of Clinical Psychiatry found that the use of antidepressant drugs was associated with an increased risk for the development of dementia. The researchers used the Taiwan National Health Research Database to perform a retrospective analysis of patients who were diagnosed with major depression and later developed dementia. “Treatment with tricyclic antidepressants was associated with a reduced risk of dementia, whereas treatment with SSRIs, MAOIs, heterocyclic antidepressants, and other antidepressants was associated with an increased risk of dementia,” they concluded.
Lee, C. W. S., Lin, C. L., Sung, F. C., Liang, J. A., & Kao, C. H. (2016). Antidepressant Treatment and Risk of Dementia: A Population-Based, Retrospective Case-Control Study. The Journal of Clinical Psychiatry, 77(1), 1-478.