Psychedelics and Psychosis: The Limitations and Risks of Chaos Consciousness


From Psychedelic Support: “Part of how psychedelics work is by increasing the amount of entropy, or chaos, in the brain. In fact, in a paper titled, ‘The Entropic Brain: A Theory of Conscious States Informed by Neuroimaging Research with Psychedelic Drugs,’ neuropsychopharmacologist Dr. Robin Carhart-Harris and his co-authors explore this very nature of psychedelics. They propose that conditions like depression, obsessive-compulsive disorder (OCD), and addiction result from too much order, or rigidity, in certain parts of the brain. Psychedelics, they argue, may help heal these conditions by disrupting that rigidity, through a mechanism much like shaking a snow globe.

Courtesy Dr. Erica Zelfand

Psychedelics appear to disrupt the neural patterns upon which rigid patterns of thought and behavior – such as those seen in depression, OCD, and addiction – rest. The accompanying graphic, which I’ve adapted from a similar image found in Carhart-Harris’ paper, shows how some of us are on the rigid, or low chaos, end of the consciousness spectrum, and some of us are more on the entropic, or high chaos end.

If we think of psychosis and mania as high chaos states, we can see how taking a chaos-increasing medicine like LSD might just push someone with a propensity towards mania or psychosis over the edge. When a patient’s brain is in the middle of a blizzard, after all, they don’t need their metaphorical snow globe shaken. Dr. Carhart-Harris and his team have also performed other studies in which the brain scans of people on psychedelics were compared to baseline images. This work reveals that psychedelics enhance neural crosstalk – the phenomenon by which novel connections are made between parts of the brain that don’t normally communicate with one another. […]

Someone with depression whose thoughts are focused on a very tight loop of negative, self-denigrating sentiments may very well benefit from a little increased cross talk. More neural connections might allow them to realize that life can actually be pretty awesome (or at least bearable), and that so many things are interconnected. They may realize that it’s not so scary after all to take the risk of asking somebody out on a date, to read more about geometry, science, or self-growth, or to spend a little money on a stylish new haircut.

Someone in a manic or psychotic state, however, doesn’t need a nudge in that direction. In fact, they’re already at high risk of seeing synchronicity where there is none, being overly familiar (as Dan was with me), becoming obsessed with fractals (or whatever has caught their interest), and racking up credit card debt in the pursuit of whimsies. It is perhaps for these reasons that most if not all of the studies on psychedelic medicine exclude those with a personal history of Bipolar 1 or psychosis from enrolling.”

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  1. As a living fossil, I feel an obligation to describe in more concrete terms the relatively safe use of hallucinogens. Avoid them if you have numerous perceptual distortions of vision, hearing, time sense, etc. Psychiatric diagnoses don’t matter but omnipresent sensory distortions do. Being a first-order relative of someone who does have them is also a warning sign for your own consumptions of hallucinogens.
    I’ve cribbed and paraphrased these items from my copy of The Hallucinogens, by Hoffer and Osmond (1967). It’s been out of print for years, but it’s a good item for you collectors to seek.

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    • My experience in this field 🙂 led me to conclude long ago that such pre/proscriptions can only represent the experiences and perspectives of the one making them. If I were to offer my own opinion, it would be that the most inarguable “never” would be to never mix any psych drugs with psychedelics, unless you’re prepared to experience intense epiphanies about how poisonous they are.

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      • Well, that goes without saying. You’d be wasting your time if you were already under the influence of antipsychotics and be more likely to freak out on antidepressants and/or the jumpers prescribed for ADHD. I do know a few things, oldhead.

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        • Wasn’t speaking to you in particular so much as anyone who might think their neurotoxins would not be one of the systemic crises a psychedelic experience would keep them focused on. I imagine it could be pretty awful, though illuminating.

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  2. One of the items I did miss in the article was the idea of having mental health workers take hallucinogens to understand the experiences their psychotic patients are having. I hope it wasn’t because Humphry Osmond, one of psychiatry’s blackest sheep, encouraged the practice for his staff members when he was superintendent at Weyburn Hospital, Saskatchewan (he also insisted on converting the hospitals “seclusion rooms” into refuges patients could voluntarily visit when overstimulated).

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    • I’d advocate more for any “mental health” worker to take Haldol or Abilify for a few weeks before they’re allowed to prescribe anything. Might create a little more compassion, though the compassion bar is pretty low at this point.

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      • They’d also have to come off such alleged medications for some time before they were mentally fit to prescribe anything more toxic than aspirin or vitamin C. The antidepressant advocates would be the worst off, as their convalescent time might stretch into years.

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      • You’re right about the major hallucinogens like LSD, psilocybin, mescaline, et. al., but there are some little known ones like adrenochrome and adrenolutin that are pretty close, aren’t psychedelic and also provide prolonged experiences that can go on for days from single doses. You can steal some asthmatic’s adrenaline and let it sit until it turns pink before you snort it, if you want to try, but I’ll pass, thank you.

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