Adolescents at Risk for Psychosis Do Worse On Antipsychotics

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In a study of 53 adolescents at risk for psychosis, researchers from Canada and the U.S. looked at treatment with antidepressants, antipsychotics, and no...

WHO Says Newer Antipsychotics Most Costly, Least Effective Strategy

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In an analysis of neuropsychiatric conditions in sub-Saharan Africa and South East Asia, the World Health Organization found that inpatient treatment of schizophrenia with...

ADHD Overtreated in Relatively Younger Children

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An 11-year study of 937,943 children in British Columbia found that boys who were relatively younger than their classmates were 41% more likely to...

SSRIs Cause Delayed Head Growth and Premature Birth

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In a study of 7,696 pregnant women, researchers in the Netherlands and the U.S. found that SSRIs caused slower head growth and premature birth....

Rise of Antipsychotics in Children

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Researchers at Johns Hopkins explore the use of antipsychotics in children, finding a dramatic rise in off-label prescribing with little oversight or research into...

Risk of Death in the Elderly Trebled With Antipsychotics

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In a nine-year study of all 2,224 residents of Leppävirta, Finland who were 65 years old or older, researchers found that the 332 residents...

Psychotropics Accelerate Cognitive and Functional Decline

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Researchers at Johns Hopkins, The Mayo Clinic, Harvard Medical School, Duke and others found in a study of 230 Alzheimer's patients tracked over four...

Antidepressant Use Associated with Brain Atrophy and Lesions in Elderly

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In a study of 630 elderly Manhattanites without dementia, researchers from the Netherlands found that antidepressant use was associated with significantly more brain atrophy,...

Antidepressant Use and Cognitive Impairment After Menopause

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A study of 6,998 postmenopausal women followed over 7.5 years found that antidepressant use correlated with a 70% increased risk of cognitive impairment. The...

Serotonin and Depression: A Disconnect Between the Advertisements and the Scientific Literature

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MIA bloggers Jonathan Leo and Jeffrey Lacasse review the Serotonin Hypothesis as represented in advertising and as verified in scientific literature, finding a disturbing...

Long-Term Antipsychotic Treatment Causes Brain Tissue Loss

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In 211 patients studied for up to 14 years, Nancy Andreason et al. found measurable brain tissue loss associated with antipsychotic use. The results...

CBT Helpful For Benzo Discontinuation

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CBT helps in benzo discontinuation, over and above relaxation training and contact with a therapist. Published in Behaviour Research and Therapy. Abstract →       ...

Potential Adverse Effects of Discontinuing Psychotropic Drugs

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Abrupt discontinuation can paradoxically cause the same effects as both medications and illness itself, this study in the Journal of Psychosocial Nursing and Mental...

Avoiding Antipsychotic Sedation Can Improve Outcome

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Sedation from antipsychotics can be mistaken for negative symptoms as well as increase noncompliance, this study in the African Journal of Psychiatry says, and...

Cumulative Risk of Impairment and Death From Anticholinergic Medication

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The New York Times reports that a two-year longitudinal study of over 13,000 men and women over 65 found that anticholinergic medications, which include many...

Antipsychotics for Dementia: Not Justified and Risky

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In a study of antipsychotics used to treat 75,445 patients in nursing homes in the United States, researchers from Harvard Medical School, Columbia and...

Better Recovery and Less Relapse Without Meds: A 20-Year Study

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Researchers at the University of Illinois College of Medicine found, in a 20-year prospective study of 139 psychotic patients, that patients had a far...

60 Minutes to Cover Antidepressant/Placebo Controversy This Sunday

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Lesley Stahl interviews Irving Kirsch of the Placebo Studies Program at Harvard Medical School this Sunday's edition of 60 Minutes. Stahl says the implication...

Some Avoid Antipsychotics Because They Value Psychosis

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Side effects, mistrust, stigma, forgetfulness and lack of insight have all been studied as reasons that up to 75% of people with a schizophrenia...

Benzo Discontinuation Improves Quality of Life and Reduces Symptoms of Schizophrenia

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Researchers in Japan find that tapering or reducing benzodiazepines has a positive effect on quality of life, verbal and working memory, and psychiatric symptoms...

Antidepressants Have No Effect On Bipolar Depression

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In a review of 68 articles published between 2005 and 2011, Israeli researchers found that most well-controlled studies failed to show a significant effect of...

England Seeks to Stop Antipsychotics For Dementia

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English health minister Paul Burstow is seeking to outlaw the 'silent scandal' of inappropriate antipsychotics for dementia by proposing legislation that imposes up to...

Antipsychotic Use Does Not Correlate With Conversion to Psychosis

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Researchers in Brazil find, in a meta-analysis, that only 30% of youth deemed to be of ultra high risk of psychosis do in fact...

David Healy Critiques Gibbons’ Reanalysis of Antidepressants and Suicide

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David Healy critiques the reanalysis by Robert Gibbons of antidepressants and suicidality in children and adolescents that was reported on this page yesterday. He...

Cognitive Therapy Shown to be Effective For Schizophrenia

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Researchers report in the February issue of Archives of General Psychiatry that cognitive therapy improved both positive and negative symptoms in "low-functioning" patients with...