Tag: STAR*D

Investigators Who Blew the Whistle On STAR*D Fraud Call for Retraction...

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A letter that Ed Pigott and Jay Amsterdam sent to Ned Kalin, editor-in-chief of the American Journal of Psychiatry.

Winding Back the Clock: What If the STAR*D Investigators Had Told...

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The STAR*D Study has been cited as real-world evidence of the efficacy of antidepressants. In truth, it told of a failed paradigm of care.

New Data Reveal the Full Extent of STAR*D Failure

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The initial study, which has been used to promote antidepressants, employed outcome switching to hide poor results.

Reanalysis of STAR*D Study Suggests Overestimation of Antidepressant Efficacy

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Reanalysis of the original primary outcome measure in the STAR*D study suggests STAR*D findings inflate improvement on antidepressant medication and exclusion criteria in conventional clinical trials results in overestimation of antidepressant efficacy.

SSRI Ineffective at Treating Depression in Individuals with Chronic Kidney Disease

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Dr. Madhukar Trivedi and colleagues find that the SSRI sertraline does not reduce depressive symptoms any more than placebo in people with Chronic Kidney Disease.

Large-Scale Study Reveals Arbitrariness of DSM Depression Diagnosis

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A new study on the depression symptoms of over three-thousand patients challenges the criteria used for diagnosing major depression with the latest Diagnostic and Statistical Manual (DSM-5). Current diagnostic systems are based on an assumption that the symptoms of depression point to a common underlying ā€œillness," but research suggests that this framework may be outdated and oversimplified.