Wednesday, December 1, 2021

The Visual Illusion of Efficacy in Psychiatric Drug Trials

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Published reports of clinical trials of psychiatric drugs typically include a graphic showing the efficacy of the study drug in reducing symptoms of the...

Anatomy of an Industry: Commerce, Payments to Psychiatrists and Betrayal of the Public Good

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The 2013 federal Open Payments legislation, which requires pharmaceutical companies to disclose their direct payments to physicians, was expected to help counter the corrupting...

A Short History of Tardive Dyskinesia: 65 Years of Drug-Induced Brain Damage That Rolls...

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Psychiatry has long turned a blind eye to the full scope of harm associated with TD. New TD drugs "work" by further impairing brain function.

The Latest “Breakthrough Therapy”: Expensive New Drugs for Tardive Dyskinesia

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The increased prescribing of antipsychotics, which frequently cause a brain injury that manifests as tardive dyskinesia, has provided pharmaceutical companies with a lucrative new market opportunity.

An FDA Whistleblower’s Documents: Commerce, Corruption, and Death

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In 2008, a reviewer of psychiatric drugs at the FDA, Ron Kavanagh, complained to Congress that the FDA was approving a new antipsychotic that was ineffective and yet had adverse effects that increased the risk of death. Twelve years later, a review of the whistleblower documents reveal an FDA approval process that can lead to the marketing of drugs sure to harm public health.

Do Antipsychotics Protect Against Early Death? A Review of the Evidence

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Psychiatry is now claiming that research has shown that antipsychotics reduce mortality among the seriously mentally ill. A critical review of the literature reveals that this claim is best described as the the field's latest "delusion" about the merits of these drugs.

The Charade of New Drug Approvals for Schizophrenia

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The FDA recently approved lumateperone for schizophrenia. A review of the clinical trials reveals a testing process that is fatally flawed, and a new drug coming to market that doesn't provide a clinically meaningful benefit.

The Whistleblower and Penn: A Final Accounting of Study 352

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After 18 years, the full story of the scientific corruption in a study of paroxetine for bipolar disorder, and the psychiatrist who blew the whistle.

Medication-Free Treatment in Norway: A Private Hospital Takes Center Stage

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At the Hurdalsjøen Recovery Center in Norway, patients with a long history of psychiatric hospitalizations are tapering from their medications and, in a therapeutic environment that emphasizes a good diet, exercise, and asking patients "what do they want in life," are leaving their old lives as chronic patients behind.
veteran suicides

Screening + Drug Treatment = Increase in Veteran Suicides

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For the past 15 years, the VA's suicide prevention efforts have focused on getting veterans screened and treated for psychiatric disorders, with antidepressants a first-line therapy. This effort has caused veteran suicide rates to steadily rise.

Suicide in the Age of Prozac

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During the past twenty years, the American Foundation for Suicide Prevention and American psychiatry have adopted a "medicalized" approach to preventing suicide, claiming that antidepressants are protective against suicide. Yet, the suicide rate in the United States has increased 30% since 2000, a time of rising usage of antidepressants. A review of studies of the effects of mental health treatment and antidepressants on suicide reveals why this medicalized approach has not only failed, but pushed suicide rates higher.
antidepressants

Do Antidepressants Work? A People’s Review of the Evidence

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After a meta-analysis of RCTs of antidepressants was published in Lancet, psychiatry stated that it proved that "antidepressants" work. However, effectiveness studies of real-world patients reveal the opposite: the medications increase the likelihood that patients will become chronically depressed, and disabled by the disorder.

Soteria Israel: A Vision from the Past is a Blueprint for the Future

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In Israel, there is a budding Soteria movement that foretells of a possible paradigm shift in care. The thought is that such care may become a first-line treatment for newly psychotic patients.

Psychiatry Defends Its Antipsychotics: A Case Study of Institutional Corruption

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Jeffrey LIeberman and colleagues have published a paper in the American Journal of Psychiatry stating that there is no evidence that psychiatric drugs cause long-term harm, and that the evidence shows that these drugs provide a great benefit to patients. A close examination of their review reveals that it is a classic example of institutional corruption, which was meant to protect guild interests.

Lancet Psychiatry Needs to Retract the ADHD-Enigma Study

Lancet Psychiatry, a UK-based medical journal, recently published a study that concluded brain scans showed that individuals diagnosed with ADHD had smaller brains. That conclusion is belied by the study data. The journal needs to retract this study. UPDATE: Lancet Psychiatry (online) has published letters critical of the study, and the authors' response, and a correction.

The Case Against Antipsychotics

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This review of the scientific literature, stretching across six decades, makes the case that antipsychotics, over the long-term, do more harm than good. The drugs lower recovery rates and worsen functional outcomes over longer periods of time.

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