Thirty-three years ago, in August 1983, an article titled Suicide Associated with Akathisia and Depot Fluphenazine Treatment appeared in the Journal of Clinical Psychopharmacology. The authors were Katherine Shear, MD, Allen Frances, MD, and Peter Weiden, MD.
Here are some quotes, interspersed with my comments/observations:
“Akathisia is a common and distressing side effect of neuroleptic medication that can be difficult to recognize and treat. Several previous reports mention maladaptive behavioral consequences, such as poor compliance with prescribed medication and aggressive or self-destructive outbursts. We are reporting suicides in two young Hispanic men who had developed severe akathisia after treatment with depot fluphenazine. Depression with suicidal behavior has been observed following fluphenazine injection, but suicide associated with akathisia has not been previously noted.”
Fluphenazine is a neuroleptic drug of the phenothiazine class that was introduced in 1959. It is marketed as Prolixin and other brand names, and according to Wikipedia, is on the WHO’s “List of Essential Medicines, most important medications needed in a basic health system.”
The “treatment” used in each case was a depot injection of fluphenazine. This is a long-lasting injection, typically 30 days, in which the drug is lodged in a dermal or muscular mass from which it is slowly drawn into the blood stream. (Hence depot: a place where goods are stored for later distribution.)
Depot injections have some obvious convenience value, but in psychiatry are usually used to ensure compliance. Their major downside is that if the person has an adverse reaction to the drug, there’s no way to remove the stored chemicals from his body.
The authors may be correct in stating that this is the first published report of suicide associated with akathisia, but it is not the first report of suicide associated with fluphenazine. Seventeen years earlier, Dorothy West, MD, had published the following letter in the British Journal of Psychiatry, 117 (1970), 718-9:
Dangers of Fluphenazine
A new drug is being widely used in the treatment of mental illness. It is long-acting and used by injection – its name is fluphenazine (Moditen). Is this the thalidomide of the 70’s? I would like to have the opinion of other doctors. Whilst it is still new maybe we are lulled into a false sense of security, but are we justified in using a drug, which may take up to six weeks to eradicate from the tissues, without being sure of its safety? Its side effects alone are legion. A study of 13 papers gives the following:
Common side-effects reported are – lethargy, drowsiness, dizziness, muscular inco-ordination, paraesthesia, hypotension, blurring of vision, dryness of mouth, malaise, feelings of tension, confusion, nausea, vomiting, and aches and pains.
Parkinsonism is extremely common. Incidence in reports varies from 100 per cent to 24 per cent with many reports around 50 per cent. Depression is quite common and tends to be severe – 5 suicides reported and two suicide attempts. Other reported side-effects include psychotic relapse and glaucoma.
. . . . .
Back to the Shear, Frances, and Weiden paper:
CASE NO. 1
“A 23-year-old single unemployed Hispanic man had been socially withdrawn, blunted in affect, and thought disordered since his early teenage years. He was intermittently delusional with auditory hallucinations which responded to phenothiazines. He was treated in a day hospital after one of multiple hospitalizations; depot fluphenazine was used because of medication noncompliance. He received two injections of 25 mg of fluphenazine decanoate separated by 1 week, with noticeable improvement in his psychotic symptoms. He also developed akathisia and was prescribed trihexyphenadyl, 2 mg twice a day, which he probably did not take. There was no improvement in his akathisia and no anticholinergic side effects. He soon stopped attending the day hospital and a family member called a week later to say that the man had killed himself by jumping off the roof of their building. He had given no indication of being suicidal and his family believed the increased ‘nervousness’ had driven him to this desperate measure. The patient had no previous history of suicidal behavior and did not drink alcohol or use drugs.”
So, we have a young man who has been socially withdrawn and joyless since his early teens. Not surprisingly his perceptions and thinking patterns deviated from the conventional. For reasons unknown he came within the orbit of psychiatry, and had had extensive contact with the psychiatric system. He was given two depot injections of fluphenazine one week apart. His “psychotic symptoms” improved, but he developed akathisia. He was prescribed an anticholinergic agent to combat the akathisia, but apparently this was ineffective, or as the authors suggest, he didn’t take it. In any event, a week later he killed himself by jumping from the roof of a building.
We don’t know if the fluphenazine was administered involuntarily, but we do know that he had taken phenothiazine in the past and had been noncompliant. So it is reasonable to assume that there was some adverse effect. Did the day hospital psychiatrists explore the reason for this “noncompliance”? In any event, given the outcome, the phrase “depot fluphenazine was used because of medication noncompliance” is a haunting and compelling testament to psychiatric arrogance. This anonymous young man was clearly prone to acute akathisia, and his “noncompliance” was a sensible and correct response to the neuro-poisoning he was receiving from psychiatrists. He stopped attending the day hospital (again, understandably),but he had no way to get the drug out of his body. The trihexyphenidyl is an anticholinergic agent and might have mitigated the akathisia. Or perhaps he took it and it was not effective, as is frequently the case.
CASE NO. 2
“A 36-year-old non-English speaking Hispanic man was seen once in our walk-in clinic because of severe restlessness and leg cramps. Intermittent somatic symptoms and nervousness began shortly after he arrived in the United States 8 months earlier. When the symptoms worsened, he began a series of visits to hospital emergency rooms and private psychiatrists. Three weeks before the walk-in visit a Spanish-speaking psychiatrist diagnosed paranoid schizophrenia and administered depot fluphenazine. Following this injection, the patient developed a dystonic reaction and then began to complain continuously of leg cramps and restlessness. In the ensuing weeks he received numerous drugs from emergency room or private physicians, some given by injection and some by prescription. He brought bottles of thiothixene, chlorazepate, amitriptyline, meprobamate, and lorazepam to the clinic. He was agitated, paced, and begged for help. He denied symptoms of depression or suicidal ideation. He claimed he was devoted to his wife and 9-year-old daughter, but he felt his unbearable symptoms would never go away. He made good contact in a translated interview and showed no thought disorder, hallucinations, or delusions. Thorough medical examination was negative except for the parkinsonian symptoms. He had no prior history of psychiatric treatment and the family history was negative for depression, nervousness, and significant psychiatric or medical illness. Since the diagnosis was uncertain, plans were made to discontinue all medication and a follow-up appointment was scheduled. The next day he killed himself without warning by jumping in front of a subway train.”
The 36-year-old man had come to the US eight months earlier, and had begun to experience “somatic symptoms and nervousness”. This seems hardly surprising in someone who is having to adapt to a new environment, but we are provided no details with regards to his psychosocial context, other than the fact that he had a wife and 9-year-old daughter, and that he didn’t speak English. What we do know is that he visited “emergency rooms and private psychiatrists” to help with “somatic symptoms and nervousness”. One of the psychiatrists “diagnosed paranoid schizophrenia”, and gave him a depot injection of fluphenazine. He developed severe akathisia, and continued to visit emergency rooms and private psychiatrists in an attempt to gain some relief. During this period he received “numerous drugs” from these sources, some by injection, some by prescription. At this point he came to the authors’ walk-in clinic.
“He was agitated, paced, and begged for help.”
“He denied symptoms of depression or suicidal ideation. He claimed he was devoted to his wife and 9-year-old daughter, but he felt his unbearable symptoms would never go away.”
Plans were made to discontinue all the drugs, which the authors euphemistically refer to as medications, but it was too little, too late. He jumped to his death in front of a train the next day.
So, we have a healthy young man, devoted to his wife and daughter, who seeks medical help for what were probably stress-related “somatic complaints and nervousness”. Psychiatrists throw a bewildering array of drugs at him, including a depot injection of fluphenazine, which results in his death. And the only reason we know about this forgotten victim of psychiatry is because the authors wrote up and published the case. How many other thousands have died from the same kind of irresponsible drug-pushing; from the same arrogant conviction that for every human problem, psychiatry has a “safe and effective” pill?
. . . . .
Here are some more quotes from the Shear et al article:
“Akathisia is an intensely unpleasant feeling characterized by muscle discomfort, inability to sit still, continuous agitation, restlessness, and fidgety feelings. Sleep may be disturbed by an inability to lie down. Some patients say they feel like jumping out of their skin”
“The estimated incidence of akathisia with neuroleptic use ranges from 20 to 45%. Several studies using depot fluphenazine report an incidence around 35%.”
“Akathisia is a distressing symptom which may be difficult to diagnose and treat. Restlessness may be mistaken for anxiety and clinicians may err by raising neuroleptic dosage.”
“Sometimes the only effective treatment is withdrawal of the neuroleptic. Although we cannot be sure that akathisia caused the deaths of our patients, akathitic symptoms seemed to be immediate precipitants of suicidal behavior. We urge clinicians to be alert to the discomfort of akathisia and to treat it aggressively. If treatment with anticholinergics or γ-aminobutyric acid agonists fails or symptoms are especially severe, hospitalization may be indicated.”
It is clear that the authors are leaning heavily towards the conclusion that neuroleptic-induced akathisia was the immediate precipitant of both suicides.
OTHER SIMILAR REPORTS
Several similar reports have appeared in the literature for decades. Here are some examples, with relevant quotes:
Van Putten, T., MD, The Many Faces of Akathisia, Comprehensive Psychiatry, 1975, 16(1):
“AKATHISIA, a common side effect of neuroleptic therapy, is an emotional state and ‘refers not to any type or pattern of movement, but rather to a subjective need or desire to move.'”
“A 44-year-old woman with hebephrenic schizophrenia started to bang her head against the wall three days after an injection of 25 mg of fluphenazine enanthate. Her only utterance was: ‘I just want to get rid of this whole body.'”
“Akathisia is often associated with strong affects of fright, terror, anger or rage, anxiety, and vague somatic complaints.”
“On this regime, she usually developed an episode of akathisia during the week following her injection. She described several such episodes as follows: ‘I just get these attacks of tension. I don’t feel right. My stomach feels strange. It’s like I’m churning inside. I feel hostile and I hate (with intense affect) everybody.”
“Patients have described the inner restlessness and agitation of akathisia in many other ways, such as: ‘My nerves are just jumping’ I feel like I’m wired to the ceiling; I just feel impatient and nasty. I can’t concentrate; it’s like I got ants in my pants; my nerves are raw; I just feel on edge; I feel just nasty; I feel like jumping out of my skin; if this feeling continues, I would rather be dead. I can’t describe the feelings; I’m quivery from the waist up; I want to climb the walls; I feel all revved up; it’s like I got diaper rash inside.'”
“Patients with severe akathisia, however, cannot sit quietly for more than a few seconds at a time, and at times the ‘impatience musculaire’ can result in running, agitated dancing, or rocking.”
“Akathisia is tolerated very poorly by hostile paranoid patients in that they tend to misinterpret the inner agitation of akathisia as further proof that they are being poisoned or controlled by outside malevolent forces.”
Note the presumably unintended irony in the word misinterpret. In reality, they are being poisoned and controlled by outside forces!
. . . . .
Keckich, W., MD: Neuroleptics: Violence as a Manifestation of Akathisia, JAMA, 1978, Nov 10 (240) 20, 2185:
“NEUROLEPTIC medications (eg, phenothiazines, butyrophenones) are used in medicine to control psychotic symptoms and concomitant agitated and violent behavior. They also are used to control anxiety and agitation whenever minor tranquilizers (eg, benzodiazepines) would be inappropriate. Development of akathisia as a parkinsonian side effect is confirmed in the use of these drugs. Akathisia is a condition that gives rise to the subjective desire to be in constant motion, with a feeling of inner agitation and muscle tension. The patient cannot sit still and paces constantly”
“One week later the patient reported that he was more agitated at night. Since it was not known at the time that akathisia was beginning, haloperidol treatment was increased to 4 mg at bedtime to decrease the agitation. Four days later, after his evening dose of 4 mg of haloperidol, he became uncontrollably agitated, could not sit still, and paced for several hours. He complained of tightness in his muscles, rigidity, a jumpy feeling inside, and violent urges to assault anyone near him. This culminated in an assault on his dog with an intent to kill. He became frightened over his loss of control and came to the emergency room. He was given 50 mg of thioridazine hydrochloride, which brought the hostility under control but did not remove it.
He subsequently discontinued the treatment with imipramine and haloperidol. The following morning he reported that the muscle tightness, jumpy feelings, and hostility were decreased but still present. Three days after drug treatment was discontinued all of the symptoms had ceased, and he was at his baseline of difficulty once again. The half-life of haloperidol is approximately 24 hours, and this symptom relief coincided with expected excretion of the drug.
In retrospect it was apparent that he had experienced increasing akathitic side effects from the haloperidol medication, which accounted for his increasing night-time agitation and culminated in a stimulation of violent and aggressive activity.”
. . . . .
Schulte, JL, MD, Homicide and Suicide Associated with Akathisia and Haloperidol, American Journal of Forensic Psychiatry, Jan 1985, 6(2):
“The following five cases are reported to bring attention to the potential for severe violence, as a result of akathisia, following such administration of a neuroleptic for acute psychiatric symptoms. Particular emphasis is directed to an experience of sensory dissociation associated with the uncomfortable physical reactions, resulting in extreme acts of physical violence.”
CASE NO. 1
“A 23-year-old married, Salvadorian-born male, with a four-day history of progressive paranoia and disorganized behavior, had been taken by the police department to a hospital at the request of his parents. The physician insisted he receive an injection of haloperidol in the emergency room while awaiting admission to the psychiatric unit where he had previously been a patient on a number of occasions.
He tried to resist but felt he had no option with the staff and police surrounding him. He felt he was being unnecessarily delayed in being admitted to the inpatient unit. In addition, he felt he had been lied to, in that apparently he had been told he was going to see his wife who had deserted him approximately 48 hours earlier. He then escaped from the emergency room and the authorities, ran several miles to a park, tried to get a policeman to help him, escaped again and totally disrobed. Within the next 45-minute period of time, he assaulted one woman who was walking her dog and attempted to rape her. When pulled off by the husband, he proceeded down the street, broke down the front door of a house where an 81-year-old lady was sleeping. He severely beat her with his fists, ‘to a pulp’, by his own description. Following which he found knives and stabbed her repeatedly, resulting in her death. Then, after being confronted in the street by a policeman who sprayed him with Mace, he returned through the house, exiting the back door where he ran into another woman with her child. He repeatedly stabbed the woman in front of the child, whereupon he moved on to the next person he encountered, a woman whom he severely assaulted and stabbed to the extent that an eye was lost and an opening into the anus was created resulting in major surgery and serious residual problems, including a colostomy. He was then finally captured and subdued by eight policemen and hospitalized.
He had ten previous psychiatric hospitalizations between 1975 and the present. All of these hospitalizations have been only a matter of hours to several days. He would always be placed on medication and released, following which he would stop taking the medication and go along until another upheaval would occur.
He had a history of problems with anger and acute paranoid beliefs leading to hyperactive behavior and one incident in which it was reported he tried to choke one of his brothers.
His description of his mental status at the time of his offense is quite striking. He describes himself as feeling almost like a spectator in a movie. He makes a point of describing how he had lost all sense of caring about anything or anyone in life. Additionally, he describes a feeling of loss of physical sensation, including feeling nothing when maced by the police. He felt enormous energy with a feeling of needing to rid himself of it.
He gives the history of having been picked up by the police on a traffic violation in 1979 and placed in jail for the first time in his life. He became angry and was given a series of haloperidol injections, becoming progressively more agitated and unmanageable to the point he was rolled up in a mattress and handcuffed in order to be transported to a psychiatric inpatient unit. In 1980, during another hospitalization, he was, despite his protests, changed from chlorpromazine to haloperidol and within hours became totally unmanageable, requiring six individuals to subdue him and place him in seclusion and restraint.” [Emphasis added]
It is noteworthy that this individual asked not to be changed from chlorpromazine to haloperidol, but his request was ignored.
Eight years later, Herrera et al confirmed in a controlled study that an increase in violent behavior was more likely with haloperidol than with chlorpromazine. Apparently, the individual had some intuitive awareness of this from previous experience, but as is often the case, the psychiatrists discounted his protests and gave him the haloperidol anyway.
Here are two quotes from the Herrera et al study:
“We found in a controlled study that some patients have a marked increase in violence when treated with moderately high-dose haloperidol.”
“…these patients did not show an increase in violence during a placebo period, nor did they have a history of violent behavior.”
Back to the Schulte JL article:
CASE NO. 2
“A 30-year-old man with a history of mental illness dating back seven years, with hospitalizations in three other states, was admitted to the hospital on six counts of burglary. His diagnosis was paranoid schizophrenia, and he had been found not guilty by reason of insanity by the courts. The admission note by the psychiatrist stated, ‘He is somewhat paranoid, but says he has side effects from most tranquilizers.’ On the third day of hospitalization, he was referred to the psychiatrist by nurses because of difficulty getting to sleep. No evidence of aggressiveness or self-injurious behavior was charted that day in the nurses’ notes. The psychiatrist prescribed haloperidol, 5mg. three times a day, which was begun the next day, with three doses administered with Cogentin, 2mg twice a day. Nurses’ notes that day stated, ‘He was very anxious about being in the hospital and threatened to kill himself if he gets up the nerve.’ At 10:45 p.m., notes stated, ‘He has regressed during this shift in all assessment areas. His hygiene is poor, and he is irresponsible, e.g., lying on the floor without shoes or socks.’ He refused medication initially at 5 p. m., and stated that phenothiazines, ‘fuck me up.’ He finally took the medication but then stated angrily, ‘Now I’ll really get crazy.’ He ranted loudly and profanely for 30 minutes. He took his 9 p.m. medication and started his haranguing again, only louder and more threatening. ‘l’ll kill all of you mother-fuckers before I leave here,’ He was found in his room at 6:50 a.m., having hung himself with a bed sheet. A letter from his attorney to the hospital had stated that ‘medications caused him problems (l should perhaps state that by medications I mean psychotropic drugs).'” [Emphasis added]
CASE NO. 3
“A 52-year-old male first came to psychiatric attention eleven years earlier following an assault on his wife. He had delusions of cancer, a belief he would die and felt sexually inadequate.
He had been unsuccessfully treated with Lithium and antidepressants, as well as various tranquilizers. He had continually been an inpatient or in board and care facilities, and three and one-half months earlier, he had his medications changed to 10mg. of Haloperidol in the a.m. and 40mg. of Haloperidol at hour of sleep, with 2mg.of Artane twice daily. Each month he stated he complained to his psychiatrist of severe restlessness. He stated he had to roll over and over in bed at night and usually would be unable to get to sleep until 3 or 4 a.m. During the day, he would try to lie down but couldn’t because of his severe uncomfortableness. He described after being turned down again by the psychiatrist, he became despondent and angry, lost hope and decided if he could not ever even sleep like the rest of his boarding home mates that life wasn’t worthwhile. He secured a knife and repeatedly stabbed himself in the abdomen, was rushed to the hospital and barely survived. He remarked he could never even feel the knife when stabbing himself.” [Emphasis added]
. . . . .
Van Putten, T. MD and Marder, SR, MD, Behavioral Toxicity of Antipsychotic Drugs, J Clin Psychiatry, September 1987, 48: 9 (Suppl):
“The subjective restlessness of akathisia is usually accompanied by telltale foot movements: rocking from foot to foot while standing or walking on the spot. Akathisia is strongly associated with depression and dysphoric responses to neuroleptics and has even been linked to suicidal and homicidal behavior in extreme cases.”
“The aforementioned case literature reads convincingly: it is reasonable to conclude that akathisia, in the extreme case, can drive people to suicide or homicide.”
. . . . .
Crowner, ML, Douyon, R, et al, Akathisia and violence Psychopharmacology Bulletin, 1990: 26(1): 115-7:
“Akathisia is a common side effect of neuroleptic drugs that may present with behavioral disturbances. There have been preliminary reports on the association between violence and akathisia. We report the first observational study of this relationship. Patients studied were from a special unit for violent patients. A closed-circuit television camera was installed in each of the corners in its dayroom. Incidents of assault plus the 5 minutes preceding each assault were recorded on videotape. Participants and bystanders were rated for the motor component of akathisia. For each of nine incidents, we compared the akathisia scores for participants and for bystanders. Both victims and assailants were akathisic before about half of all incidents; bystanders rarely were. The classification of the movements we rated and the implications for further studies are discussed.”
The extraordinary irony here is that the individuals in this study “were from a special unit for violent patients,” but in fact the drug used to control this behavior was actually precipitating more violence!
. . . . .
Galynker, I, MD, PhD and Nazarian, D, MD, letter to the editor, Journal of Clinical Psychiatry, 1997, 58: 31-32:
“Case Report. Mr. A, a 47-year-old white man with a diagnosis of bipolar mood disorder, was brought to the emergency room because he was screaming in the streets. Mr. A had over 30 past psychiatric admissions associated with agitation and violence and was often discharged against medical advice. He was nearly always noncompliant with his antipsychotic medications, claiming that they made him ‘jump and lose my temper.’ Prior to the present admission, Mr. A’s daily medications included haloperidol 20 mg, lithium carbonate 1500 mg, divalproex sodium 500 mg, and benztropine 1 mg. At admission, the patient was grandiose, had loud and pressured speech, and admitted he was not taking haloperidol. He was given haloperidol 15 mg q.h.s. and benztropine 1 mg q.a.m. Within 24 hours he started pacing; became restless, agitated, and violent; complained of feeling ‘jumpy’; and attacked a staff member. On Day 5 of his hospitalization, haloperidol and benztropine were discontinued; chlorpromazine was started, and the dose was increased to 950 mg/day. Mr. A, although sedated, remained threatening and violent. On Day 13, chlorpromazine was discontinued, and haloperidol was restarted at a higher dose of 15 mg p.o. b.i.d. Mr. A again complained of ‘jumpiness’ and punched a television cabinet, causing a self-inflicted fracture. On hospital Day 17, owing to an error, haloperidol was discontinued. The patient became calmer, less irritable, displayed no angry outbursts, and required no further room restrictions. After 5 days, when the error was discovered, haloperidol was restarted at a lower daily dose of 10 mg. Within 3 days, the patient became violent and required room restriction. Haloperidol was then discontinued, the patient’s agitation and violence resolved, and a week later he was discharged. His daily medications were lithium carbonate 1500 mg (serum level = 0.9mEq/L; this dose had not been changed during his hospitalization), lorazepam 1 mg, and divalproex sodium 500 mg. On these mediations, he remained well 6 months postdischarge, his longest period as an outpatient.”
In their commentary, the authors point out:
“The fact that the jumpiness occurred with haloperidol and not with chlorpromazine is another factor indicative that Mr. A has exhibited akathisia rather than nonspecific activation of mania; this is because akathisia is more common with higher potency as compared with low-potency neuroleptics.”
and, with more candor than one customarily finds in psychiatry:
“One can also speculate that Mr. A’s rocky clinical history was related to aggressive behavior perpetuated by antipsychotic administration.”
And it is worth remembering that Mr. A’s “rocky clinical history” entailed “over 30 past psychiatric admissions associated with agitation and violence”.
. . . . .
So, since at least the early 80’s, individual psychiatrists have been drawing attention to the fact that neuroleptic drugs induce akathisia in many cases, and that in some cases this can precipitate suicide and/or homicide.
Akathisia & Antidepressants
Although it is well known that neuroleptic drugs cause akathisia, the link between antidepressants and this condition is less widely appreciated. The Wikipedia article on akathisia contains this:
“Antidepressants can also induce the appearance of akathisia, due to increased serotonin signalling within the CNS.”
. . . . .
Hamilton, MS, MD, Obler, LA, Akathisia, suicidality, and fluoxetine, J Clin Psychiatry, 1992, Nov 53(11), 401-406, write:
“The propose[d] link between fluoxetine and suicidal ideation is explained by fluoxetine-induced akathisia and other dysphoric extrapyramidal reactions.”
“The literature suggests that fluoxetine-induced extrapyramidal reactions may be a mediator of de novo suicidal ideation.”
Fluoxetine is an SSRI, marketed as Prozac, Sarafem, and other names.
. . . . .
Wirshing, WC, MD, Van Putten, T, MD, Rosenberg, J, MD, et al, Fluoxetine, Akathisia, and Suicidality: Is There a Causal Connection?, Arch Gen Psychiatry, 1992, 49(7), 580-581, write:
“We have now had experience with five such patients. All were women. None had a history of significant suicidal behavior; all described their distress as an intense and novel somatic-emotional state; all reported an urge to pace that paralleled the intensity of the distress; all experienced suicidal thoughts at the peak of their restless agitation; and all experienced a remission of their agitation, restlessness, pacing urge, and suicidality after the fluoxetine was discontinued. We describe herein five cases of what we think might be fluoxetine-induced akathisia accounting for suicidal ideation.”
Eikelenboom-Schieveld, SJM, Lucire, Y, MD, Fogleman, J, PhD, The relevance of cytochrome P450 polymorphism in forensic medicine and akathisia-related violence and suicide, Journal of Forensic and legal Medicine, 2016, 41. 65-71, wrote:
“Antidepressants have been reported as causing suicide and homicide and share the class attribute of frequently producing akathisia, a state of severe restlessness associated with thoughts of death and violence.”
“In this paper, we report our investigation into adverse drug reactions/interactions in three persons who committed homicide, two also intending suicide, while on antidepressants prescribed for stressful life events”
“Three persons committed homicide, two of which intended to commit suicide. None had been aggressive or mentally ill before getting medication. None had known that they needed to take medication regularly or how to stop taking it safely. None improved on medication, and no prescriber recognized their complaints as adverse drug reactions or was aware of impending danger. Interviews elicited accounts of restlessness, akathisia, confusion, delirium, euphoria, extreme anxiety, obsessive preoccupation with aggression, and incomplete recall of events. Weird impulses to kill were acted on without warning. On recovery, all recognized their actions to be out of character, and their beliefs and behaviours horrified them.”
. . . . .
Whitehead, PD, Causality and Collateral Estoppel: Process and Content of Recent SSRI Litigation, 2003, J Am Acad Psychiatry Law 31:377–82, wrote:
“In Tobin v. SmithKline Beecham Pharmaceuticals a jury in the U.S. District Court for the District of Wyoming found that the medication Paxil ‘can cause some individuals to commit homicide and/or suicide,’ and that it was a legal cause of the deaths in this case.”
. . . . .
Breggin, PR, MD, Suicidality, violence and mania caused by selective serotonin reuptake inhibitors (SSRIs): A review and analysis. International Journal of Risk & Safety in Medicine, 2004, 16, 31-49, wrote:
“Evidence from many sources confirms that selective serotonin reuptake inhibitors (SSRIs) commonly cause or exacerbate a wide range of abnormal mental and behavioral conditions. These adverse drug reactions include the following overlapping clinical phenomena: a stimulant profile that ranges from mild agitation to manic psychoses, agitated depression, obsessive preoccupations that are alien or uncharacteristic of the individual, and akathisia. Each of these reactions can worsen the individual’s mental condition and can result in suicidality, violence, and other forms of extreme abnormal behavior. Evidence for these reactions is found in clinical reports, controlled clinical trials, and epidemiological studies in children and adults. Recognition of these adverse drug reactions and withdrawal from the offending drugs can prevent misdiagnosis and the worsening of potentially severe iatrogenic disorders. These findings also have forensic application in criminal, malpractice, and product liability cases.”
“There are many reports and studies confirming that SSRI antidepressants can cause violence, suicide, mania and other forms of psychotic and bizarre behavior.”
. . . . .
Although there is a great deal of prima facie evidence and many case reports detailing the neuroleptic/antidepressant link to suicide and violence, there has not to my knowledge been a definitive large-scale study by American psychiatry of the link between psychiatric drugs and the murder/suicides that are occurring with increased frequency.
And the great question is: why not? Why is this urgent, life-threatening issue not afforded the highest priority by the APA, NIMH, and university psychiatry departments? Is their self-serving need to protect psychiatry from the consequences of its errors eclipsing their ethical integrity and their sense of responsibility?
DSM & Akathisia
In this regard, it’s interesting to see how psychiatric drug-induced akathisia has been handled in the various editions of DSM.
DSM-III-R (1987) makes no specific reference to neuroleptic or antidepressant-induced akathisia. There are, however, a number of statements in the chapter on “schizophrenia” which clearly (and deceptively) ascribe symptoms of akathisia and tardive dyskinesia to “schizophrenia” itself. For instance:
“In addition, odd mannerisms, grimacing, or waxy flexibility may be present [in schizophrenia]. (p 190)
“Almost any symptom can occur as an associated feature [of schizophrenia]. The person may appear perplexed, disheveled, or eccentrically groomed or dressed. Abnormalities of psychomotor activity—e.g., pacing, rocking, or apathetic immobility—are common.” (p 190) [Emphasis added]
In reality, most of the pacing, grimacing, and rocking exhibited by people labeled schizophrenic is a direct result of neuroleptic drug poisoning, and not an associated feature of the so-called illness itself.
“Dysphoric mood is common [with schizophrenia], and may take the form of depression, anxiety, anger, or a mixture of these.” (p 190)
Anxiety and anger are also direct effects of neuroleptic poisoning for many people.
“Although violent acts performed by people with this disorder often attract public attention, whether their frequency is actually greater than in the general population is not known. What is known is that the life expectancy of people with Schizophrenia is shorter than that of the general population because of an increased suicide rate and death from a variety of other causes.” (p 191)
As is clear from the material quoted earlier, suicide is frequently a result of akathisia. The phrase “death from a variety of other causes” is unclear.
. . . . .
DSM-IV (1994) was markedly more honest in acknowledging the existence of neuroleptic-induced akathisia. In fact, this was included as an actual diagnosis in the fourth edition. It was coded as 333.99, and 2½ pages (744-746) were devoted to its description. Here are some quotes:
“In its most severe form, the individual may be unable to maintain any position for more than a few seconds.” (p 744)
“The subjective distress resulting from akathisia is significant and can lead to noncompliance with neuroleptic treatment. Akathisia may be associated with dysphoria, irritability, aggression, or suicide attempts. Worsening of psychotic symptoms or behavioral dyscontrol may lead to an increase in neuroleptic medication dose, which may exacerbate the problem. Akathisia can develop very rapidly after initiating or increasing neuroleptic medication. The development of akathisia appears to be dose dependent and to be more frequently associated with particular neuroleptic medications. Acute akathisia tends to persist for as long as neuroleptic medications are continued, although the intensity may fluctuate over time. The reported prevalence of akathisia among individuals receiving neuroleptic medication has varied widely (20%-75%).” (p 745) [Emphasis added]
Note the reference in the third line above to “irritability, aggression, or suicide attempts“. In fact, as the material quoted earlier makes clear, neuroleptic-induced akathisia has been causally-linked to actual homicides and suicides. This understatement was clearly deliberate, as Allen Frances, MD, architect of DSM-IV, was also one of the authors of the Shear et al paper quoted earlier, which linked neuroleptic-induced akathisia to actual completed suicides.
“Neuroleptic-Induced Acute Akathisia may be clinically indistinguishable from syndromes of restlessness due to certain neurological or other general medical conditions, to nonneuroleptic substances, and to agitation presenting as part of a mental disorder (e.g., a Manic Episode).” (p 745)
In other words, people who are experiencing neuroleptic-induced acute akathisia are at risk of being assigned a “diagnosis” of “bipolar disorder”!
“Serotonin-specific reuptake inhibitor antidepressant medications may produce akathisia that appears to be identical in phenomenology and treatment response to Neuroleptic-Induced Acute Akathisia. Akathisia due to nonneuroleptic medication can be diagnosed as Medication-Induced Movement Disorder Not Otherwise Specified.” (p 745) [Bold face in original]
“Individuals with Depressive Episodes, Manic Episodes, Generalized Anxiety Disorder, Schizophrenia and other Psychotic Disorders, Attention-Deficit/Hyperactivity Disorder, dementia, delirium, Substance Intoxication, (e.g., with cocaine), or Substance Withdrawal (.e.g., from an opioid) may also display agitation that is difficult to distinguish from akathisia.” (p 745-746) [Bold face in original]
Which prompts one to wonder how many people who have been assigned these so-called diagnoses were actually suffering from one of the toxic effects of neuroleptic drugs or SSRI’s. It is also entirely plausible, as DSM-IV suggests, that many of these individuals would have been “treated” with even higher doses of neuroleptics!
. . . . .
The entry in DSM-IV-TR (2000) is identical to that in DSM-IV except for the following addition:
“Although the atypical [newer] neuroleptic medications are less likely to cause akathisia than the typical [older] neuroleptics, nonetheless, these medications do cause akathisia in some individuals.” (p 801)
. . . . .
DSM-5 is remarkably less frank concerning psychiatric drug-induced akathisia than was DSM-IV. The name Neuroleptic-Induced Acute Akathisia was changed to Medication-Induced Acute Akathisia and the entry is given a total of four-and-a-half lines of text:
“333.99 (G25.71) Medication-Induced Acute Akathisia
Subjective complaints of restlessness, often accompanied by observed excessive movements (e.g., fidgety movements of the legs, rocking from foot to foot, pacing, inability to sit or stand still), developing within a few weeks of starting or raising the dosage of a medication (such as a neuroleptic) or after reducing the dosage of a medication used to treat extrapyramidal symptoms.” (p 711) [Bold face in original]
There is no reference to the fact that, as earlier psychiatric authors had stated, the condition can be so unbearable as to drive people to suicide and even homicide.
There is, however, an interesting admission in a separate, also brief, entry:
“333.72 (G24.09) Tardive Dystonia
333.99 (G25.71) Tardive Akathisia
Tardive syndrome involving other types of movement problems, such as dystonia or akathisia, which are distinguished by their late emergence in the course of treatment and their potential persistence for months to years, even in the face of neuroleptic discontinuation or dosage reduction.” (p 712) [Bold face in original]
In other words, neuroleptic-induced akathisia can persist for years, even if the person stops taking the drugs! But even granting this admission, it is clear that DSM-5 is markedly down-playing the significance and seriousness of neuroleptic-induced akathisia. And it is also clear from elsewhere in the text that the agenda here is to protect the reputation of the neuroleptic drugs:
“The term neuroleptic is becoming outdated because it highlights the propensity of antipsychotic medications to cause abnormal movements, and it is being replaced with the term antipsychotic in many contexts.” (p 709)
Note the deceptive use of the passive voice (“is becoming outdated”). In reality, psychiatrists are consciously and deliberately phasing out the term “neuroleptic” in an attempt to conceal, or at least not draw attention to, the severe and potentially life-threatening neurotoxic effects of these drugs.
But the more important question is why has the APA eliminated the DSM-IV category “neuroleptic-induced akathisia” that ran to 2 ½ pages, and replaced it with the more general “medication-induced acute akathisia”, which runs to 4 ½ lines? Why has this dangerous and relatively widespread adverse effect been so downplayed? On page 809 of the DSM-5 text there is a section called Highlights of Changes from DSM-IV to DSM-5, but there is no explanation for the change there. There is a note in this section referring the reader to “An expanded description of nearly all changes…” on the APA website. The link leads to an article titled “Highlights of Changes from DSM-IV-TR to DSM-5“. But the article contains no reference to the change in question.
So we don’t know the APA’s justification for suppressing information about this potentially devastating adverse effect. But we do know that neuroleptic drugs are being prescribed for an increasing range of problems, and are even being prescribed to toddlers for temper tantrums and to nursing home residents for “management problems”. Some have even acquired “block-buster” sales status. It is clearly in pharma’s interests to suppress this information and it is consistent with psychiatry’s hand-in-glove relationship with pharma that they should oblige their generous benefactors in this way. Remember, 69% of the DSM-5 workforce were in the pay of pharma while working on the revision.
Despite the early, and very clear, statements from individual psychiatrists linking psychiatric drugs to murder/suicides, the psychiatric leadership has consistently failed to address this link. Instead, they deceptively attribute these incidents to a lack of psychiatric “treatment”, and they call for legal enforcement of even more drugging.
On June 9, 2016, Maria Oquendo, MD, President of the APA, wrote a post in support of the Senate’s so-called Mental Health Reform Bill. The post was standard psychiatric propaganda, including the inane 21% annual and 50% lifetime prevalence of “mental illness”. The reality is that if one can invent illnesses at will and arbitrarily reduce the “diagnostic” thresholds of these “illnesses”, one can produce any prevalence numbers one chooses.
The post also drew attention to the fact that there were 41,000 suicides in the US in 2013, and asserted that “…we continue to fail people with mental illness every day.”
In other words, more psychiatric treatment would reduce the suicide rate. But meanwhile, we have no data on how many of these individuals were in the throes of neuroleptic or antidepressant-induced akathisia. And as long as psychiatry and pharma are controlling the research agenda, such information will be systematically repressed.
As I’ve stated many times, psychiatry is intellectually and morally bankrupt. They are adamantly resistant to anything resembling critical self-appraisal, and there are no depths of deception and spin to which they will not go, to suppress the reality and the consequences of their drug-pushing depredations. Neuroleptic and antidepressant drugs induce some individuals to take their own lives and/or the lives of others. Neuroleptic and antidepressant drugs are almost certainly the proximate causes of many of the mass shootings that have plagued our country for almost twenty years. How much longer can psychiatry sustain this dreadful, self-serving deception?
Senator John McCain and Congressman David Jolly have introduced bills in their respective chambers that if enacted will require the Veterans Administration to conduct a comprehensive study of the link between psychiatric drugs and veterans’ suicides. It will be an enormous step forward if these bills become law. It is also an interesting reflection that these bills were initiated by politicians, and not by psychiatrists, who present themselves as caring professionals acting in the best interests of their so-called patients.
If you live in the US, please encourage your representatives to support the McCain and Jolly bills (S 3410 and H 4640).
Mad in America hosts blogs by a diverse group of writers. These posts are designed to serve as a public forum for a discussion—broadly speaking—of psychiatry and its treatments. The opinions expressed are the writers’ own.
If I sit on a tack, I will feel pain. That is my body’s way of letting me know that harm is being done and that I need to do something to stop further damage.
But more likely than not, I will get sent to Psychotherapy, to Street Drugs, to Alcohol, to Prescription Drugs, to Motivationalism, or to Religion. All of these things give me ways to avoid feeling the pain, and to come to believe that the problem is within me.
Likewise, if my social standing is being denigrated, if I am being marginalized, if my biography is being voided, I will feel emotional and psychological distress and pain. It is there to tell me that something is wrong and that if I don’t do something about it, my ability to go on living could come into question.
But likely I will get sent to the same places, to Psychotherapy, to Street Drugs, to Alcohol, to Prescription Drugs, to Motivationalism, or to Religion. Always, they try to tell me that the problem is within me, and that my misery is simply because I will not submit and accept things as they are.
They don’t want me to remove the tack. They don’t want me to fight to redress the wrongs which continue to shape my life. They want me to accept the same life of lies and denial that they live.
So tempted to write in George McGovern.
But I know the importance of today, and I know that I can send messages and make statements in other ways.
Like most of us, Hillary Clinton is clearly influenced by the Civil Rights Movement, the Anti-War Movement, and the Women’s Movement. And we can see this.
But she started out as a White Suburban Republican, and she even worked on the Barry Goldwater Campaign. We can still see this too.
Very clearly stated!
And in fact, the authors of DSM-I might have agreed with you. In that edition almost all the “diagnoses” contained the word “reaction”: e.g., “schizophrenic reaction”, “dissociative reaction”, “obsessive compulsive reaction”, etc.. The idea was that the problematic thoughts, feelings, and/or behaviors were essentially reactions to difficulties that people encountered, rather than disease entities.
Of course all this was swept away in DSM-II as psychiatry jettisoned anything that threatened their spurious “within-the-individual” dogma.
Thank you for that information about DSM-I. I had not known that.
It’s no wonder that they have to “revise” the DSM all the time because they’re always practicing slight of hand on the public. Now you see it and now you don’t. They must cover their tracks and make sure that the public never realizes that people have been duped. I believe that psychiatry has proven that it is lacking ethics and morals because of the unholy marriage it contracted with the drug companies. it needs to be removed as a specialty of medicine and psychiatrists sent packing to find other employment. There is no doubt that there are some psychiatrists who practice ethics and morals in the way that they deal with people but the profession as a whole is totally lacking respectability and any kind of validity. The drug companies couldn’t get away with what they do without the collusion of psychiatry. Psychiatrists could refuse to force these drugs on people but that hardly ever happens. So, who is ultimately responsible for this epidemic of “mental illness” that we have on our hands?
Psychiatrists! Without a doubt – and those other professionals who go along in the hoax for the sake of the crumbs that fall from the rich man’s table.
Thanks for pointing out some of the serious adverse effects of the neuroleptics and antidepressants, Philip. It’s a shame the psychiatric community as a whole is completely ignorant or in denial of the ADRs of the drugs they prescribe, at least all my psychiatrists were. I’m one of the many people who had the common adverse effects of an antidepressant misdiagnosed as “bipolar.” Then I suffered from extreme tardive dyskinesia and akethesia, from what’s medically known as anticholinergic toxidrome poisoning according to the drug interactions of the drugs I was forced to take, which was misdiagnosed as “the classic symptoms of schizophrenia” by my psychiatrist. Thankfully, most the adverse, iatrogenically induced symptoms went away when I was weaned off the toxic psychiatric drugs. It is a shame the psychiatric industry collectively is so stupid, delusional, unethical, and/or immoral, however.
Thanks for this. The adverse effects of the anticholinergic drugs are not widely known, but here’s the abstract from Ogino et al 2013, Benefits and limits of anticholinergic use in schizophrenia: focusing on its effect on cognitive function. https://www.ncbi.nlm.nih.gov/pubmed/24102938
“All currently available antipsychotic drugs are the dopamine D2 receptor antagonists and are capable of producing extrapyramidal side-effects (EPS). Anticholinergic drugs are primarily used to treat EPS or prevent EPS induced by antipsychotics in the treatment of psychosis and schizophrenia. However, they can cause a variety of distressing peripheral side-effects (e.g. dry mouth, urinary disturbances, and constipation) and central adverse effects (e.g. cognitive impairment, worsening of tardive dyskinesia, and delirium). Disturbances in cognitive abilities are cardinal features of schizophrenia from its earliest phases and account for much of the functional disability associated with the illness. It is likely that long-term concomitant administration of anticholinergics exacerbates the underlying cognitive impairment in patients with schizophrenia and subsequently affects patients’ quality of life. Thus, current treatment guidelines for schizophrenia generally do not recommend the prophylactic and long-term use of anticholinergics. However, the high use of long-term anticholinergic drugs with antipsychotics has been identified as an important issue in the treatment of schizophrenia in several countries. To assess the benefits and limits of anticholinergic use in psychosis and schizophrenia, this article will provide a brief review of the pharmacology and clinical profiles of anticholinergic drugs and will focus on their effects on cognitive function in schizophrenia, particularly during the course of the early phase of the illness. In addition, we will address the effects of discontinuation of anticholinergics on cognitive function in patients with schizophrenia and provide a strategy for adjunctive anticholinergic use in patients treated with long-acting injectable antipsychotics.”
It’s standard psychiatric stuff, but the authors are clear concerning the adverse effects of the anticholinergics.
Usually I appreciate your articles for their humour, but, this time, you have skipped that and gone straight to the centre of my horror.
Personally, I think this thing they call akathisia often is simply overdosing. (Except with Haldol. That seems to be a real part of the drug. Or maybe, in my brief encounter with haldol, they were just overdosing big time.) When you are experiencing the overdosing, the ‘health care personnel’ should back off, but don’t. That is the horror.
I had all kinds of psychiatric drug effects that I put up with for years (crippling of the hands, minor tardive kinesia), but the diffierence with akathisia is that it can’t be ignored. It is dying on the spot. Realizing how completely health care professionals would prioritize ’emergency’ prophylactic drugging over patient was the end of any remnants of relationship there for me.
Sure, the system is based on administering miracle drug treatments, so they know which side their bread is buttered on. But I think a realization of general overdrugging will creep over the whole population eventually, maybe starting with families and patients dying from cancer drugs, going blind from statins and blood pressure drugs, and so on. Mental health is really so much about sllencing the inconvenient (old, young, and dependent), it won’t probably be the first place health professionals are called on to back off.
Really, reading your article gave me chills. But thanks, as always.
Thanks for this comment. There is indeed a great deal of horror and chill in the case reports, and in psychiatry’s callous, self-serving suppression of this information.
Thank You, Philip.
I had two suicide attempts myself on Fluphenazine depot and several years of disibility in the early 1980s in Ireland.
Allen Frances reported suicidal reaction in 1983 to Fluphenazine Depot medication. But it’s well known that this drug causes akathesia which triggers suicide – so why are there not more reports???
My own Adverse Drug Events were not reported as the Psychiatrist looking after me in Ireland was promoting Fluphenazine on behalf of its manufacturer – He had doctored my records; and doctored his own University Research papers.
After stopping these drugs in 1984 I made Recovery and a return to normal functioning, through Psychotherapy and have remained well since.
(I had asked for Psychotherapy at the beginning in 1980 but was refused this option and injected with Fluphenazine depot instead).
Thanks for this.
Why indeed are there not more reports? Because psychiatry routinely suppresses anything that casts their “safe and effective treatments” in a bad light.
I think there’s a collective tolerance towards drug induced Fatality among the “Untermensch” – they just don’t like hearing about it Officially.
So seeing this unworkable situation, what should we be trying to do about it?
1. Outlaw forced treatment
2. Outlaw giving psych meds to children
3. Enforce mandatory reporting, any therapy on children must be reported to Child Protection. Otherwise doctors become accomplice child abusers, as no one is looking after the child’s interests.
4. Take the profit out of Medical Child Abuse ( formerly Munchausen’s By Proxy ), parents are responsible for all harms inflicted, and disinheritance of one’s child is prohibited.
Move from Talk to Action, Please Join
In my view, giving psychiatric drugs to children is essentially on a par to giving illegal streets drugs or alcohol or tobacco to children. The only differences are that the former are widely believed to be medications, and the fact that they are prescribed by physicians has fostered the mistaken belief that they are necessary and safe.
Legislation generally does not outstrip societal consensus. And that, in my view, is why we must concentrate first on exposing the fraud. There is, I think, a “skeptical majority” who have mixed feelings about psychiatry, and it is when we connect with these individuals that legislation will become possible.
That said, I think the McCain-Jolly initiative in Congress is a great step forward that could yield fruit.
I think we should be trying right now to outlaw the giving of psych drugs to children. Maybe it won’t happen yet, but we should be pushing.
I also say that we have to shut down all facets of the fix my kid industry. The way to do this is simply to enforce mandatory reporting. Failure to report in suspected cases of child abuse is already supposed to be a felony.
The middle-class family has always used its ability to hire private practice doctors as a way of defining itself. So we have now doctors who advertise to parents that they will always hold parents as blameless and make their kids more compliant. Some use drugs, some are anti-drug.
Using drugs is medical experimentation upon children. Doing it with talk therapy alone is helping children to be used as marital pawns. No one is looking out for the interests of the child.
So I say, either these doctors report, or we get them into handcuffs and prosecute them.
Move From Talk To Action, Please Join:
What do you think about this:
I am convinced that it is intended to promote medical child abuse ( formerly Munchausen’s Syndrome by Proxy ), and then to take the adults who survive and complete the process by turning them into total basket cases.
And I feel especially confident in saying this because of how involved I was in helping to put someone from a similar church into our state prison for molesting his daughters. He and the wife had already gotten the eldest boy removed from the home by escalating conflicts with him and then getting him diagnosed with ~~mental illness~~ and put on drugs.
I learned how their church works and how their entire belief system depends upon child scapegoating.
Germany is one of the countries which has a Universal Jurisdiction law. See, it was not that many years ago that Germany got itself handed a new constitution. In Germany NGO’s can bring criminal indictments.
And they have put this to good use, having war crimes indictments against Donald Rumsfeld and G. W. Bush. And these do not expire. So don’t expect either of these two to be going to October Fest anytime soon.
How many agree with me that we should get these doctors who are giving drugs to children charged with Crimes Against Humanity?
“…Information type: Media and commentaries
Source: Sanofi UK
Specialities: Mental health and illness
This is being discontinued due to unpredictability of supply of fluphenazine decanoate from third party manufacturer in South Africa. Production will cease mid-2018 and the product is expected to remain available in UK up until end of 2018 (based on current usage).
This early notification is intended to give clinicians sufficient time to identify and begin administering alternative therapies to their patients. Dose equivalence information can be found in the BNF. It is recommended that no patient commence treatment with Modecate where it is expected that treatment will be required beyond end of 2018.
Medical information at Sanofi can be contacted for further information; tel 08453727101, email: [email protected]….”
“…Mr Hunt said that independent medical examiners – which were first recommended at the 2005 inquiry into the murders by GP Dr Harold Shipman – would bring a ‘profound change in our ability to learn from unexpected or avoidable deaths’…”
“…In a statement to the Commons, Mr Hunt said: ‘Grieving relatives will be at the heart of the process and will have the chance to flag any concerns about the quality of care and the cause of death to an independent clinician, meaning we get to the bottom of any systemic failings much more quickly.’…”