Antidepressants

About half of the large antidepressant trials are biased enough to be considered “seeding trials,” according to the researchers.

In this new study, exposure to maternal anxiety in utero also harmed child development.

New research finds the negative drug effects most commonly associated with initiating antidepressant discontinuation are anxiety, suicidal thoughts, vomiting, and rashes.

Research sheds light on the impact of antidepressants on sexual dysfunction, emphasizing the need for patient-physician communication.

While the study can’t confirm causality, it does contradict the notion that antidepressants reduce suicide at the population level.

New study reveals: 2 in 3 people need more than the current antidepressant benefits to consider them worthwhile.

A new study in Frontiers of Pharmacology finds that antidepressant use during pregnancy is linked to reduced motor skills in children at 2 years...

In adolescent depression treatment, those who received a placebo but thought they received Prozac improved more than those who received the drug and knew it.

Experts advocate limiting antidepressant use to only the most severe cases of depression, emphasizing the need for social and psychological interventions.

Researchers found that rats born to mothers given the antidepressant Prozac during pregnancy or breastfeeding exhibited varied behavioral and developmental effects, with implications for the understanding of antidepressant impacts during human pregnancies.

Reduced brain volumes due to SSRI exposure in pregnancy was not explained by maternal depression alone.

Selective publication bias in top psychiatry journals was not explained by the quality of the studies, but by financial ties to pharma.

Researchers find that SSRIs increase suicide attempts up to age 24, and have no preventative effect at any age, even for those at high risk of suicide.

For those with severe depression, inpatient CBT was effective but the adding antidepressants did not improve treatment outcomes.

The initial study, which has been used to promote antidepressants, employed outcome switching to hide poor results.

Response and remission rates were the same in the drug versus placebo groups, and Lexapro increased suicidality sixfold.

Moncrieff et al. respond to the contradictory and, in some cases, false concerns raised by these critics of their serotonin review.

Genetic testing may help reduce the length of time people experience the harmful effects of antidepressant drugs, but it is not helpful for predicting efficacy.

World Psychiatry article challenges conventional antidepressant prescription practices.

A new Cochrane review details the lack of evidence for antidepressants in the treatment of chronic pain.

New research by Jim van Os and Peter Groot finds that using hyperbolic tapering to discontinue antidepressants reduces withdrawal effects.

Males taking antidepressants were at 100 times the risk of erectile dysfunction compared with the healthy population and more than three times the risk even after controlling for other variables.

Study reveals most patients are dissatisfied with prescribers' support when discontinuing antidepressants.

New study finds polypharmacy for 73% of older adults on antidepressants, with 56% at risk of harmful drug interactions.

New guidance for primary care doctors in the UK on antidepressant discontinuation acknowledges severe and long-lasting withdrawal symptoms.