Antidepressant Trials “Hijacked for Marketing Purposes,” Researchers Say

30
About half of the large antidepressant trials are biased enough to be considered “seeding trials,” according to the researchers.

Antidepressant Use in Pregnancy Harms Child Development, Untreated Maternal Depression Shows Benefit

2
In this new study, exposure to maternal anxiety in utero also harmed child development.

Common Side Effects Leading to Antidepressant Discontinuation

1
New research finds the negative drug effects most commonly associated with initiating antidepressant discontinuation are anxiety, suicidal thoughts, vomiting, and rashes.

Antidepressant Use Linked to Sexual Dysfunction, Why Aren’t Prescribers Discussing It?

1
Research sheds light on the impact of antidepressants on sexual dysfunction, emphasizing the need for patient-physician communication.

Antidepressant Use Tightly Correlates with Increased Suicide Rates

4
While the study can’t confirm causality, it does contradict the notion that antidepressants reduce suicide at the population level.
3D illustration of a matrix with tablets and the words risks and benefits. Concept of clinical trials results

Two Out of Three Find Antidepressant Effects Not Worth Burdens

1
New study reveals: 2 in 3 people need more than the current antidepressant benefits to consider them worthwhile.

Antidepressant Exposure In Utero May Negatively Impact Motor Skills in 2-Year-Old Children

1
A new study in Frontiers of Pharmacology finds that antidepressant use during pregnancy is linked to reduced motor skills in children at 2 years...
3D render of placebo pills isolated over wood background

Placebo Effect—Not Antidepressants—Responsible for Depression Improvement

15
In adolescent depression treatment, those who received a placebo but thought they received Prozac improved more than those who received the drug and knew it.

Stop Using Antidepressants Except for “the Most Severe Depression,” Experts Say

14
Experts advocate limiting antidepressant use to only the most severe cases of depression, emphasizing the need for social and psychological interventions.
Pregnant woman visiting young psychologist

Animal Study Shows Impact of Prozac in Pregnancy on the Child

0
Researchers found that rats born to mothers given the antidepressant Prozac during pregnancy or breastfeeding exhibited varied behavioral and developmental effects, with implications for the understanding of antidepressant impacts during human pregnancies.

SSRI Use During Pregnancy Alters the Child’s Brain Development

6
Reduced brain volumes due to SSRI exposure in pregnancy was not explained by maternal depression alone.
Pile of pills in blister packs background

Psychiatric Journals’ Pro-Pharma Publication Bias Hides Suicide Risk of Antidepressants

14
Selective publication bias in top psychiatry journals was not explained by the quality of the studies, but by financial ties to pharma.
Top View of Girl Sits on Bed with Scattered Pills. Little Child Sitting on Gray Badcover Near Opened Packing of Medicines Keeps Head with Hands. Unhappy Childhood Concept

Antidepressants Increase Suicide Attempts in Youth; No Preventative Effect

15
Researchers find that SSRIs increase suicide attempts up to age 24, and have no preventative effect at any age, even for those at high risk of suicide.

No Benefit for Adding Antidepressants to CBT in Severe Depression

7
For those with severe depression, inpatient CBT was effective but the adding antidepressants did not improve treatment outcomes.

New Data Reveal the Full Extent of STAR*D Failure

20
The initial study, which has been used to promote antidepressants, employed outcome switching to hide poor results.

Lexapro for Children: Drug With No Meaningful Benefit and Increased Suicidality Gets FDA Approval

12
Response and remission rates were the same in the drug versus placebo groups, and Lexapro increased suicidality sixfold.
Battle of the brains and war of wit concept as two opposing open human brain symbols fighting as a debate or dispute metaphor and an icon for creative competition in a 3D illustration style.

Pharma CEO, Others Attempt Contradictory Critiques of Serotonin-Debunking Study

12
Moncrieff et al. respond to the contradictory and, in some cases, false concerns raised by these critics of their serotonin review.
brain against blue dna strand with chemical structures

No Difference in Antidepressant Effectiveness After Genetic Testing

5
Genetic testing may help reduce the length of time people experience the harmful effects of antidepressant drugs, but it is not helpful for predicting efficacy.

Do Not Prescribe Antidepressants for Mild to Moderate Depression or at First Visit

5
World Psychiatry article challenges conventional antidepressant prescription practices.

Study Highlights Lack of Evidence for Antidepressants in Treatment of Chronic Pain

1
A new Cochrane review details the lack of evidence for antidepressants in the treatment of chronic pain.

Hyperbolic Tapering off Antidepressants Limits Withdrawal

6
New research by Jim van Os and Peter Groot finds that using hyperbolic tapering to discontinue antidepressants reduces withdrawal effects.

What Is the Risk of Permanent Sexual Dysfunction from Antidepressants?

4
Males taking antidepressants were at 100 times the risk of erectile dysfunction compared with the healthy population and more than three times the risk even after controlling for other variables.

Prescribers Often Fail to Support Patients Discontinuing Antidepressants, Study Finds

7
Study reveals most patients are dissatisfied with prescribers' support when discontinuing antidepressants.

Alarming Overprescription Patterns for Older Adults on Antidepressants

2
New study finds polypharmacy for 73% of older adults on antidepressants, with 56% at risk of harmful drug interactions.

New Guidance on Antidepressant Withdrawal for Doctors in the UK

6
New guidance for primary care doctors in the UK on antidepressant discontinuation acknowledges severe and long-lasting withdrawal symptoms.